Fig. 1 · Structure
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1,10-Decanedithiol
PROTAC Linker
1,10-Decanedithiol is a versatile PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This linear aliphatic dithiol provides a flexible and stable backbone, enabling the effective conjugation of target-specific ligands and E3 ligase recruiters. Its biological activity facilitates enhanced degradation of target proteins, making it a valuable tool for drug discovery and research into targeted protein degradation mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1191-67-9 |
| Applications | PROTAC Linker |
| Formula | C10H22S2 |
| Molecular Weight | 206.41 |
| SMILES | SCCCCCCCCCCS |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.