Fig. 1 · Structure
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1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperazine
PROTAC Linker
1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperazine serves as a versatile PROTAC linker, facilitating the development of Protein Degradation Targeting Chimera (PROTAC) molecules. This compound is designed to enhance the stability and efficacy of PROTACs by linking the target protein to an E3 ligase, promoting ubiquitination and subsequent degradation. Its unique structure allows for fine-tuning in drug design, making it a valuable reagent for researchers in the fields of targeted protein degradation and therapeutic development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1245505-23-0 |
| Applications | PROTAC Linker |
| Formula | C17H27BN2O2 |
| Molecular Weight | 302.23 |
| SMILES | O1B(OC(C)(C)C1(C)C)C2=CC=C(C=C2)CN3CCNCC3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.