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Cyclobutane-1,3-dicarboxylic acid

PROTAC Linker

Cyclobutane-1,3-dicarboxylic acid functions as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs) for targeted protein degradation. This chemical scaffold enhances the design of bifunctional molecules that recruit E3 ligases to specific proteins, thereby promoting their ubiquitination and subsequent degradation. Its application is critical in the study of protein regulation and therapeutic intervention in various diseases, including cancers.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	62184-63-8
Applications	PROTAC Linker
Formula	C₆H₈O₄
Molecular Weight	144.13
SMILES	O=C(O)C1CC(C(=O)O)C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.