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TAM Receptor
Inhibitory Selectivity
| Catalog No. | Inhibitor Name | Mer | Axl | Tyro3 | Other |
|---|---|---|---|---|---|
| A10996 | Cabozantinib | *** | |||
| A10153 | BMS-777607 | ** | **** | **** | VEGFR2/KDR,c-Met,Kit |
| A13741 | R428 | ** | RON,Met,FLT3 | ||
| A14143 | UNC2250 | **** | * | VEGFR2/KDR,c-Met,Kit | |
| A15904 | UNC2025 | **** | ** | ** | |
| A15776 | TP-0903 | ** | FLT3 | ||
| A15917 | NPS-1034 | *** | |||
| A13003 | LDC1267 | *** | * | *** | Met |
| A14276 | UNC2881 | **** | * | * |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
12 Item(s)
per page
| Catalog No. | Product Name | Application | Product Information |
|---|---|---|---|
A10996 SALE |
XL184 free base (Cabozantinib) |
VEGFR inhibitor |
XL184 free base (Cabozantinib) is a small molecule designed to inhibit multiple receptor tyrosine kinases, specifically MET and VEGFR2.
|
A15864 |
SGI-7079 |
Axl inhibitor |
SGI-7079 ,a novel selective Axl inhibitor, inhibits tumor growth in a dose dependent manner and is a potential therapeutic target for overcoming EGFR inhibitor resistance.
|
A15776 SALE |
TP-0903 |
AXL Inhibitor |
TP-0903 is a potent and selective Axl kinase inhibitor with IC50 of 27 nM.
|
A16257 |
Glesatinib hydrochloride |
MET/Axl inhibitor |
Glesatinib hydrochloride is an inhibitor of the MET and Axl receptor tyrosine kinase pathways, which drive tumour growth when altered.
|
A14411 |
Gilteritinib (ASP2215) |
FLT3/Axl inhibitor |
Gilteritinib is a potent FLT3/AXL inhibitor, which showed potent antileukemic activity against AML with either or both FLT3-ITD and FLT3-D835 mutations.
|
A13741 SALE |
R428 |
Axl Inhibitor |
R428 is a selective small molecule inhibitor of Axl kinase, which showed activity to blocks tumor spread and prolongs survival in models of metastatic breast cancer.
|
A10153 SALE |
BMS-777607 |
c-Met inhibitor |
BMS-777607 is a MET tyrosine kinase inhibitor that binds to c-Met protein, or HGFR, preventing binding of HGF and disrupting the MET signaling pathway.
|
A14276 SALE |
UNC2881 |
Mer tyrosine kinase inhibitor |
UNC2881 is a specific Mer tyrosine kinase inhibitor
|
A14143 |
UNC 2250 |
Selective Mer Kinase inhibitor |
UNC2250 is a potent and selective Mer Kinase inhibitor.
|
A13003 SALE |
LDC1267 |
TAM Receptor inhibitor |
LDC1267 is a highly selective TAM(Tyro3, Axl and Mer) kinase inhibitor with IC50 of <5 nM/8 nM/29 nM for Tyro3,Axl and Mer respectively.
|
A15917 |
NPS-1034 |
c-Met inhibitor |
NPS-1034 is a dual Met/Axl inhibitor with IC50 of 48 nM and 10.3 nM, respectively.
|
A13805 |
UNC569 |
Mer Inhibitor |
UNC569 is a novel small-molecule MER inhibitor with efficacy against acute lymphoblastic leukemia in vitro and in vivo. UNC569 is the first small-molecule Mer inhibitor. UNC569 inhibited Mer activation and downstream signaling through ERK1/2 and AKT.
|
12 Item(s)
per page
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