TAM Receptor

Catalog No.Inhibitor Name MerAxlTyro3Other
A10996Cabozantinib
***
A10153BMS-777607
**
****
****
VEGFR2/KDR,c-Met,Kit
A13741R428
**
RON,Met,FLT3
A14143UNC2250
****
*
VEGFR2/KDR,c-Met,Kit
A15904UNC2025
****
**
**
A15776TP-0903
**
FLT3
A15917NPS-1034
***
A13003LDC1267
***
*
***
Met
A14276UNC2881
****
*
*

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. XL184 free base (Cabozantinib)

    Catalog No. A10996
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    VEGFR inhibitor
    XL184 free base (Cabozantinib) is a small molecule designed to inhibit multiple receptor tyrosine kinases, specifically MET and VEGFR2. Learn More
  2. SGI-7079

    Catalog No. A15864
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    Axl inhibitor
    SGI-7079 ,a novel selective Axl inhibitor, inhibits tumor growth in a dose dependent manner and is a potential therapeutic target for overcoming EGFR inhibitor resistance. Learn More
  3. TP-0903

    Catalog No. A15776
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    AXL Inhibitor
    TP-0903 is a potent and selective Axl kinase inhibitor with IC50 of 27 nM. Learn More
  4. Glesatinib hydrochloride

    Catalog No. A16257
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    MET/Axl inhibitor
    Glesatinib hydrochloride is an inhibitor of the MET and Axl receptor tyrosine kinase pathways, which drive tumour growth when altered. Learn More
  5. Gilteritinib (ASP2215)

    Catalog No. A14411
    FLT3/Axl inhibitor
    Gilteritinib is a potent FLT3/AXL inhibitor, which showed potent antileukemic activity against AML with either or both FLT3-ITD and FLT3-D835 mutations. Learn More
  6. R428

    Catalog No. A13741
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    Axl Inhibitor
    R428 is a selective small molecule inhibitor of Axl kinase, which showed activity to blocks tumor spread and prolongs survival in models of metastatic breast cancer. Learn More
  7. BMS-777607

    Catalog No. A10153
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    c-Met inhibitor
    BMS-777607 is a MET tyrosine kinase inhibitor that binds to c-Met protein, or HGFR, preventing binding of HGF and disrupting the MET signaling pathway. Learn More
  8. UNC2881

    Catalog No. A14276
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    Mer tyrosine kinase inhibitor
    UNC2881 is a specific Mer tyrosine kinase inhibitor Learn More
  9. UNC 2250

    Catalog No. A14143
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    Selective Mer Kinase inhibitor
    UNC2250 is a potent and selective Mer Kinase inhibitor. Learn More
  10. LDC1267

    Catalog No. A13003
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    TAM Receptor inhibitor
    LDC1267 is a highly selective TAM(Tyro3, Axl and Mer) kinase inhibitor with IC50 of <5 nM/8 nM/29 nM for Tyro3,Axl and Mer respectively. Learn More
  11. NPS-1034

    Catalog No. A15917
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    c-Met inhibitor
    NPS-1034 is a dual Met/Axl inhibitor with IC50 of 48 nM and 10.3 nM, respectively. Learn More
  12. UNC569

    Catalog No. A13805
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    Mer Inhibitor
    UNC569 is a novel small-molecule MER inhibitor with efficacy against acute lymphoblastic leukemia in vitro and in vivo. UNC569 is the first small-molecule Mer inhibitor. UNC569 inhibited Mer activation and downstream signaling through ERK1/2 and AKT. Learn More

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