Biological Activity
LDC1267 is a highly selective TAM(Tyro3, Axl and Mer) kinase inhibitor with IC50 of <5 nM/8 nM/29 nM for Tyro3,Axl and Mer respectively.
Targets
Mer | Tyro3 | Axl | ||
<5 nM | 8 nM | 29 nM |
In vitro | DMSO | Warmed: 89 mg/mL (158.77 mM) | |
Water | Insoluble | ||
Ethanol | Warmed: 2 mg/mL (3.56 mM) | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 17.84 mL | 89.2 mL | 178.4 mL |
0.5 mM | 3.57 mL | 17.84 mL | 35.68 mL |
1 mM | 1.78 mL | 8.92 mL | 17.84 mL |
5 mM | 0.36 mL | 1.78 mL | 3.57 mL |
*The above data is based on the productmolecular weight 560.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A13003 |
---|---|
Actions | Inhibitor |
CAS No. | 1361030-48-9 |
Formula | C30H26F2N4O5 |
M. Wt | 560.55 |
Purity | >98% |
Synonyms | LDC 1267, LDC-1267 |
SMILES | CCOC1=CN(N=C1C(=O)NC2=CC(=C(C=C2)OC3=C4C=C(C(=CC4=NC=C3)OC)OC)F)C5=C(C=C(C=C5)F)C |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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