Cabozantinib S-malate

Catalog No.: A11349
multiple receptor tyrosine kinases inhibitor
Cabozantinib S-malate (XL184 S-malate) is a potent multiple receptor tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50s of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively.
Grouped product items
Product Name Price Stock Qty
Cabozantinib S-malate 50mg
$99.00
In stock
Cabozantinib S-malate 100mg
$171.00
In stock
Cabozantinib S-malate 500mg
$506.00
In stock
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Adooq Products cited in reputable paper
Adooq's Cabozantinib S-malate has been cited by 2 publications
  • Paula Sagmeister, .et al. , J Hepatocell Carcinoma, 2022, Jul 9;9:595-607 PMID: 35845819
  • Aya Hasan Alshammari, .et al. , Biochem Pharmacol, 2022, Mar;197:114914 PMID: 35041812
  • Biological Activity
    Discription Cabozantinib S-malate (XL184 S-malate) is a potent multiple receptor tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50s of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively.
    Targets
    Target Value
    Product Information
    Catalog Num A11349
    Formula C32H30FN3O10
    Molecular Weight 635.59
    CAS Number 1140909-48-3
    SMILES O=C([C@H](CC(O)=O)O)O.O=C(NC1=CC=C(C=C1)OC2=CC=NC3=CC(OC)=C(C=C23)OC)C4(CC4)C(NC5=CC=C(C=C5)F)=O
    Synonyms XL184 S-malate; BMS-907351 S-malate
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 91 mg/mL (143.17 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 14 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 15.73 mL 78.67 mL 157.33 mL
    0.5 mM 3.15 mL 15.73 mL 31.47 mL
    1 mM 1.57 mL 7.87 mL 15.73 mL
    5 mM 0.31 mL 1.57 mL 3.15 mL
    Useful Calculator

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