Cabozantinib S-malate

Catalog No.: A11349

multiple receptor tyrosine kinases inhibitor

Cabozantinib S-malate

Cabozantinib S-malate Chemical Structure

CAS NO. 1140909-48-3

Cabozantinib S-malate (XL184 S-malate) is a potent multiple receptor tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50s of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively.

Availability: In stock

Package Price Qty
50 mg
$99.00
100 mg
$171.00
500 mg
$506.00
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Biological Activity

Cabozantinib S-malate (XL184 S-malate) is a potent multiple receptor tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50s of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.73 mL 78.67 mL 157.33 mL
0.5 mM 3.15 mL 15.73 mL 31.47 mL
1 mM 1.57 mL 7.87 mL 15.73 mL
5 mM 0.31 mL 1.57 mL 3.15 mL

*The above data is based on the productmolecular weight 635.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11349
Actions Inhibitor
M. Wt 635.59
Formula C32H30FN3O10
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1140909-48-3
Synonyms XL184 S-malate; BMS-907351 S-malate
SMILES O=C([[email protected]](CC(O)=O)O)O.O=C(NC1=CC=C(C=C1)OC2=CC=NC3=CC(OC)=C(C=C23)OC)C4(CC4)C(NC5=CC=C(C=C5)F)=O

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