Cabozantinib S-malate

Catalog No.: A11349

multiple receptor tyrosine kinases inhibitor

Cabozantinib S-malate

Cabozantinib S-malate Chemical Structure

CAS NO. 1140909-48-3

Cabozantinib S-malate (XL184 S-malate) is a potent multiple receptor tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50s of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively.

Availability: In stock

Package Price Qty
50 mg
$99.00
100 mg
$171.00
500 mg
$506.00
Custom Size Get quote

Free Overnight Delivery on orders over $500

Next day delivery by 10:00 a.m. Order now.

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Cabozantinib S-malate (XL184 S-malate) is a potent multiple receptor tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50s of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively.
In vitro (25°C) DMSO 91 mg/mL (143.17 mM)
Water Insoluble
Ethanol Insoluble
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 14 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.73 mL 78.67 mL 157.33 mL
0.5 mM 3.15 mL 15.73 mL 31.47 mL
1 mM 1.57 mL 7.87 mL 15.73 mL
5 mM 0.31 mL 1.57 mL 3.15 mL

*The above data is based on the productmolecular weight 635.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11349
Actions Inhibitor
CAS No. 1140909-48-3
Formula C32H30FN3O10
M. Wt 635.59
Solubility DMSO
Purity >98%
Synonyms XL184 S-malate; BMS-907351 S-malate
SMILES O=C([[email protected]](CC(O)=O)O)O.O=C(NC1=CC=C(C=C1)OC2=CC=NC3=CC(OC)=C(C=C23)OC)C4(CC4)C(NC5=CC=C(C=C5)F)=O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Tags

Product Tags

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
Keywords:buy Cabozantinib S-malate | Cabozantinib S-malate Supplier | purchase | cost | manufacturer | order | distributor | buy 1140909-48-3| 1140909-48-3 Supplier | purchase 1140909-48-3 | 1140909-48-3 cost | 1140909-48-3 manufacturer | order 1140909-48-3 | 1140909-48-3 distributor
Rewards