Axl-IN-19 is a selective inhibitor of AXL, a membrane-bound receptor tyrosine kinase, exhibiting an IC50 of 5.3 nM and a cellular KD of 6.8 nM. This compound demonstrates favorable pharmacokinetic properties in rats, characterized by low clearance and moderate bioavailability. Axl-IN-19 is primarily utilized in cancer research to explore the role of AXL signaling in tumor progression and metastasis.
Axl-IN-19 is a selective inhibitor of AXL, a membrane-bound receptor tyrosine kinase, exhibiting an IC50 of 5.3 nM and a cellular KD of 6.8 nM. This compound demonstrates favorable pharmacokinetic properties in rats, characterized by low clearance and moderate bioavailability. Axl-IN-19 is primarily utilized in cancer research to explore the role of AXL signaling in tumor progression and metastasis.
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