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RU-301 is a pan-TAM receptor inhibitor, exerts pan-TAM inhibitory activity by binding at the interface between Gas6 and the Ig1 domain of the respective TAMs with Kd and IC50 values of 12 μM and 10 μM, respectively.
| In vitro | DMSO | 84 mg/mL (174.83 mM) | |
| Water | Insoluble | ||
| Ethanol | 2 mg/mL (4.16 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.81 mL | 104.07 mL | 208.13 mL |
| 0.5 mM | 4.16 mL | 20.81 mL | 41.63 mL |
| 1 mM | 2.08 mL | 10.41 mL | 20.81 mL |
| 5 mM | 0.42 mL | 2.08 mL | 4.16 mL |
*The above data is based on the productmolecular weight 480.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A19156 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1110873-99-8 |
| Formula | C21H19F3N4O4S |
| M. Wt | 480.46 |
| Purity | >98% |
| Synonyms | RU 301; RU301 |
| SMILES | O=C(NCCNC1=CC=C(C(F)(F)F)C=C1[N+]([O-])=O)C2=CC=CC=C2SCC3=CC(C)=NO3 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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