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Biological Activity
UNC569 is a novel small-molecule MER inhibitor with efficacy against acute lymphoblastic leukemia in vitro and in vivo. UNC569 is the first small-molecule Mer inhibitor. UNC569 inhibited Mer activation and downstream signaling through ERK1/2 and AKT.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.22 mL | 126.1 mL | 252.21 mL |
| 0.5 mM | 5.04 mL | 25.22 mL | 50.44 mL |
| 1 mM | 2.52 mL | 12.61 mL | 25.22 mL |
| 5 mM | 0.5 mL | 2.52 mL | 5.04 mL |
*The above data is based on the productmolecular weight 396.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13805 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1350547-65-7 |
| Formula | C22H29FN6 |
| M. Wt | 396.5 |
| Purity | >98% |
| Synonyms | UNC-569, UNC 569 |
| SMILES | CCCCNC1=NC=C2C(=NN(C2=N1)CC3CCC(CC3)N)C4=CC=C(C=C4)F |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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