UNC3133 is a selective and orally bioavailable inhibitor of the Mer tyrosine kinase (MerTK), demonstrating an IC50 of 8.1 nM. This compound exhibits preferential inhibition of the TAM receptor family, particularly with approximately sevenfold selectivity for Axl and tenfold selectivity for Tyro3, while also showing comparable activity against Flt3. UNC3133 is applicable in research focused on anti-tumor and anti-infection mechanisms, providing insights into therapeutic strategies targeting these pathways.
UNC3133 is a selective and orally bioavailable inhibitor of the Mer tyrosine kinase (MerTK), demonstrating an IC50 of 8.1 nM. This compound exhibits preferential inhibition of the TAM receptor family, particularly with approximately sevenfold selectivity for Axl and tenfold selectivity for Tyro3, while also showing comparable activity against Flt3. UNC3133 is applicable in research focused on anti-tumor and anti-infection mechanisms, providing insights into therapeutic strategies targeting these pathways.
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