Fig. 1 · Structure

Cat. No.: A13741
CAS No.: 1037624-75-1
Formula: C₃₀H₃₄N₈
Mol. Weight: 506.64

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Other Forms

Form	MW
R428 This page	506.64
(R)-Bemcentinib	506.66

R428

Name: R428
Brand: Adooq Bioscience
SKU: A13741
Availability: InStock
Rating: 5 (1 reviews)

Cat. No. A13741 CAS 1037624-75-1

Axl Inhibitor

R428 is a selective small molecule inhibitor of Axl kinase, which showed activity to blocks tumor spread and prolongs survival in models of metastatic breast cancer.

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Biological Activity

Target & Activity

Target	Activity	Value
Axl		14 nM

Cellular Effect

Cell Line	Activity	Value	Description	Reference
4T1	IC50	0.94 μM	Antiproliferative activity against mouse 4T1 cells highly expressing AXL after 72 hrs by MTT assay	[PMID: 35279611]
BaF3	IC50	117.2 nM	Antiproliferative activity against mouse BaF3 stably expressing human TEL-AXL incubated for 72 hrs	[PMID: 33957388]
GES1	IC50	> 60 μM	Cytotoxicity against human GES1 cells after 72 hrs by MTT assay	[PMID: 35279611]
HeLa	IC50	< 30 nM	Inhibition of recombinant AXL in human HeLa cells after 1 hr by ELISA	[PMID: 26555154]
MCF-10A	IC50	> 60 μM	Cytotoxicity against human MCF-10A cells after 72 hrs by MTT assay	[PMID: 35279611]
MDA-MB-231	IC50	2.84 μM	Antiproliferative activity against human MDA-MB-231 cells highly expressing AXL after 72 hrs by MTT assay	[PMID: 35279611]

Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1037624-75-1
Applications	Axl Inhibitor
Formula	C₃₀H₃₄N₈
Molecular Weight	506.64
Synonyms	BGB324
SMILES	C1CCN(C1)[C@H]2CCC3=C(CC2)C=C(C=C3)NC4=NN(C(=N4)N)C5=NN=C6C(=C5)CCCC7=CC=CC=C76

Storage & Solubility

In Vitro Solubility

Reported Solubility

Solvent	Reported Solubility
DMSO	Warmed: 6 mg/mL (11.84 mM)
Water	Insoluble
Ethanol	Insoluble

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

In Vivo Preparation

Concentration: 1 mg/mL
Vehicle: 5% DMSO+corn oil

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Publications

1 publication citing this product

Ofra Novoplansky, .et al. , J Exp Clin Cancer Res, 2024, Nov 20;43(1):308 PMID: 39567998