R428

Catalog No.: A13741

Axl Inhibitor

R428

R428 Chemical Structure

CAS NO. 1037624-75-1

R428 is a selective small molecule inhibitor of Axl kinase, which showed activity to blocks tumor spread and prolongs survival in models of metastatic breast cancer.

Availability: In stock

Package Price Qty
2 mg
$50.00
5 mg
$90.00
10 mg
$160.00
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Biological Activity

R428 is a selective small molecule inhibitor of Axl kinase, which showed activity to blocks tumor spread and prolongs survival in models of metastatic breast cancer.
Targets
Axl
14 nM
In vitro (25°C) DMSO Warmed: 6 mg/mL (11.84 mM)
Water Insoluble
Ethanol Insoluble
In vivo 5% DMSO+corn oil 1 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.74 mL 98.69 mL 197.38 mL
0.5 mM 3.95 mL 19.74 mL 39.48 mL
1 mM 1.97 mL 9.87 mL 19.74 mL
5 mM 0.39 mL 1.97 mL 3.95 mL

*The above data is based on the productmolecular weight 506.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13741
Actions Inhibitor
CAS No. 1037624-75-1
Formula C30H34N8
M. Wt 506.64
Purity >98%
Synonyms BGB324, BGB 324, BGB-324, R-428
SMILES C1CCN(C1)[[email protected]]2CCC3=C(CC2)C=C(C=C3)NC4=NN(C(=N4)N)C5=NN=C6C(=C5)CCCC7=CC=CC=C76
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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