UNC8969 is a dual inhibitor targeting MERTK and AXL, exhibiting IC50 values of 1.1 ± 0.8 nM for MERTK and 5.3 ± 2.7 nM for AXL. With a half-life (T1/2) of 7.3 hours following intravenous administration at 5 mg/kg in mice, UNC8969 demonstrates significant biological activity. This compound is valuable for research applications focused on cancer biology, particularly in studies investigating the roles of MERTK and AXL in tumor progression and immune modulation.
UNC8969 is a dual inhibitor targeting MERTK and AXL, exhibiting IC50 values of 1.1 ± 0.8 nM for MERTK and 5.3 ± 2.7 nM for AXL. With a half-life (T1/2) of 7.3 hours following intravenous administration at 5 mg/kg in mice, UNC8969 demonstrates significant biological activity. This compound is valuable for research applications focused on cancer biology, particularly in studies investigating the roles of MERTK and AXL in tumor progression and immune modulation.
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