Catalog No.
Product Name
Application
Product Information
Citations
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Antidepressant Agent
MeSeI is an antidepressant agent that weakly inhibits monoamine oxidase (MAO) A and B, exhibiting an IC50 value of 198.8 µM. It modulates the activity of dopamine receptor D2 and norepinephrine receptors α2 and β1, demonstrating antidepressant-like effects in animal models. MeSeI is administered orally, making it a convenient candidate for further research into mood disorders and related pharmacological applications. -
Dopamine-Blocking Agent
Oxiperomide is an orally active dopamine-blocking agent that primarily targets dopamine receptors. It exhibits significant antagonistic activity, making it useful for studying dopaminergic signaling pathways and related neurophysiological processes. This compound is applicable in research involving neuropsychiatric disorders and the exploration of dopamine's role in various physiological functions. -
Drug Metabolite
Piribedil N-oxide is a metabolite of the dopamine receptor agonist Piribedil, primarily functioning as a drug metabolite. This compound retains the ability to interact with dopamine receptors, contributing to studies on dopamine signaling pathways and pharmacokinetics. Its characterization is essential for understanding the metabolic fate of Piribedil and its potential implications in neurological research and therapeutic applications. -
Dopamine D2 Receptor Agonist
Quinelorane is a potent dopamine D2 receptor agonist. It has been shown to facilitate semen ejaculation while inhibiting penile erection in rat models. This compound is valuable for investigating mechanisms underlying sexual dysfunction and related therapeutic approaches. -
Stable Isotope
Molindone-d8 is a deuterated form of the antipsychotic agent molindone, primarily used as a stable isotope in scientific research. Its primary mechanism involves dopamine receptor antagonism, reducing the effects of dopamine and helping to mitigate symptoms of schizophrenia. This labeled compound is particularly valuable in pharmacokinetic studies and metabolic research, allowing for precise tracking and analysis of drug behavior in biological systems. -
Stable Isotope
Ropinirole-d3 is a deuterated analog of Ropinirole, primarily targeting D3 and D2 dopamine receptors. As a potent agonist, Ropinirole exhibits a Ki value of 29 nM for the D2 receptor, alongside pEC50 values of 7.4, 8.4, and 6.8 for human D2, D3, and D4 receptors, respectively. This stable isotope is useful in pharmacokinetic studies and can provide insights into the mechanism of action related to dopaminergic therapies, particularly in the context of Parkinson's disease research. -
Bisbenzylisoquinoline Alkaloid Secoderivative
S-Secoantioquine is a bisbenzylisoquinoline alkaloid secoderivative that primarily targets dopamine receptors. It exhibits weak displacement activity on the 3H-SCH 23390 binding site and demonstrates certain displacement activity on the 3H-raclopride binding site in rat striate membrane experiments. This compound is useful for research in neuropharmacology and may aid in understanding the mechanisms of dopaminergic signaling. -
D3 Receptor Agonist
PF 219061 is a selective agonist of the dopamine D3 receptor, exhibiting an EC50 of 15 nM. This compound demonstrates rapid absorption and efficient liver blood clearance, making it suitable for studying female sexual dysfunction. Its specificity for the D3 receptor allows for exploration of its potential therapeutic applications in related disorders. -
Serotonin-Norepinephrine-Dopamine Releasing Agent
4-Bromoamphetamine hydrochloride is a potent serotonin-norepinephrine-dopamine releasing agent (SNDRA) that exhibits significant stimulant effects. This compound plays a crucial role in neurological research, particularly in studies examining neurotransmitter release and potential neurotoxicity. Notably, 4-Bromoamphetamine hydrochloride has been associated with long-term depletion of serotonin, making it relevant for investigations into neurodegenerative conditions and the mechanisms of neurotransmitter regulation. -
Dopamine Receptor-blocking Agent
(±)-Butaclamol hydrochloride is a dopamine receptor-blocking agent primarily utilized in neuropharmacological research. As the (+)-enantiomer of butaclamol, it demonstrates strong binding affinity to dopamine receptors, making it useful for studying dopamine-mediated pathways. This compound is often applied in the investigation of psychiatric disorders and the development of antipsychotic medications. -
Dopamine D2 Receptor Antagonist
ADR 851 is a potent antagonist of the dopamine D2 receptor, known for its role in neurotransmitter signaling. This compound demonstrates significant activity in modulating dopaminergic pathways and has been utilized in research related to antiemetic therapies. Its effectiveness in targeting the D2 receptor makes it a valuable tool for studies investigating the mechanisms of nausea and emesis. -
Dopamine Receptor Agonist
PD-168077 is a selective agonist for the dopamine D4 receptor, exhibiting a binding affinity (Ki) of 9 nM. This compound demonstrates significant biological activity in modulating dopaminergic signaling pathways, making it a useful tool for research focused on neuropharmacology and psychiatric disorders. Its specificity for the D4 receptor allows for targeted studies in areas such as schizophrenia and addiction, facilitating the exploration of therapeutic interventions. -
Dopamine Receptor Antagonist
(-)-OSU6162 is a potent presynaptic dopamine receptor antagonist, primarily targeting the D2 dopamine receptor subtype. It exhibits inhibitory effects on dopamine release, making it valuable for research on dopaminergic signaling and its implications in neuropsychiatric disorders. This compound is useful for studying the role of dopamine in various biological systems and can aid in the development of treatments for conditions such as schizophrenia and addiction. -
Dopaminergic Agonist
GYKI-32887 is a selective dopaminergic agonist that primarily targets dopamine receptors. This compound is notable for its ability to reduce motor activity levels in rodent models, making it a valuable tool for studying dopaminergic signaling pathways and motor function disorders. Its application spans across neuropharmacological research, particularly in understanding the mechanisms of drug action in neurological conditions. -
hD2R Activator
Boc-MIF-1-Am is a potent enhancer of the human dopamine D2 receptor, exhibiting an EC50 value of 17.82 nM. This bioconjugate of melanostatin (MIF-1) and amantadine is primarily utilized in the study of dopaminergic signaling pathways and their implications in neurological disorders. Although Boc-MIF-1-Am demonstrates key biological activity, it has been noted to exhibit mild neurotoxicity at a concentration of 200 μM in SH-SY5Y cells, making careful consideration necessary in experimental designs. -
D2 Receptor Agonist
Sumanirole is a highly selective D2 receptor full agonist, exhibiting an ED50 of approximately 46 nM. This compound is significant in the research of Parkinson's disease and restless leg syndrome, providing insights into dopaminergic signaling pathways. Its potent agonistic activity at the D2 receptor makes it valuable for exploring therapeutic strategies in these neurological disorders. -
Dopamine Receptor Control
Aripiprazole N1-oxide is a metabolite of the atypical antipsychotic drug Aripiprazole, produced through the activity of cytochrome P450 isoforms CYP2D6 and CYP3A4. This compound primarily targets dopamine receptors, influencing dopaminergic signaling pathways. Aripiprazole N1-oxide is significant in research related to psychiatric disorders, enabling the study of receptor modulation and metabolic pathways in drug efficacy and safety. -
Dopamine Receptors Agonist
Dinoxyline is a potent agonist of dopamine receptors, exhibiting high affinity with Ki values of 7 nM, 6 nM, 5 nM, and 43 nM for D1, D2, D3, and D4 receptors, respectively. This compound is valuable for investigating dopaminergic signaling pathways and their implications in neurological research. Its ability to selectively engage dopamine receptors makes it an essential tool for studies related to mood disorders, addiction, and other neurological conditions. -
D2R Antagonist
BRD5814 is a potent antagonist of the dopamine D2 receptor (D2R), a key target in the modulation of dopaminergic signaling. This compound demonstrates significant inhibitory activity, making it a valuable tool in research focused on schizophrenia and other neuropsychiatric disorders. Its application in studies of D2R-related pathways can aid in understanding the complex mechanisms underlying these conditions. -
Chlorpromazine Active Metabolite
7-Hydroxychlorpromazine hydrochloride is the active metabolite of Chlorpromazine, primarily targeting dopamine receptors. This compound is known to increase prolactin levels and enhance dopamine turnover, exhibiting notable sedative effects. Research applications include studying psychosis and investigating its efficacy in inhibiting amphetamine-induced stereotyped behaviors in rodent models. -
Dopamine Agonist
Lergotrile mesylate is a potent orally active dopamine agonist that functions primarily by activating dopamine receptors in the adenohypophysis, thereby inhibiting prolactin secretion. This mechanism contributes to its potential applications in the research of Parkinson's disease and related disorders. By modulating dopamine activity, Lergotrile mesylate serves as a valuable tool for exploring therapeutics targeting dopaminergic pathways. -
Dopamine Receptor Agonist
Disulergine is an ergot alkaloid that acts as a dopamine receptor agonist. It has been shown to inhibit prolactin secretion in rats and also suppress the release of growth hormone (GH). This compound is particularly relevant for research applications exploring the regulation of hormonal pathways and the physiological effects of dopamine receptor modulation. -
Central Dopamine Receptor Antagonist
Brl 20596 is a potent central dopamine receptor antagonist. This compound exhibits significant inhibitory activity at dopamine receptors, making it valuable for antipsychotic research. Its ability to modulate dopaminergic signaling can aid in the investigation of neuropsychiatric disorders related to dopamine dysregulation. -
CI-1007 Active Metabolite
PD-147693 is the active metabolite of the presynaptic dopamine autoreceptor agonist CI-1007, exhibiting antipsychotic activity akin to its parent compound. This reagent is utilized in neuropharmacological research to explore the mechanisms of dopaminergic signaling and evaluate potential therapeutic approaches for neuropsychiatric disorders. Its relevance extends to studies focused on dopamine receptor interactions and their implications in psychopharmacology. -
D3 Receptor Antagonist
(Rac)-GR218231 is a selective antagonist of the dopamine D3 receptor, exhibiting a pKi value of 8.9. This compound is valuable for studying the role of D3 receptors in various neurological and psychiatric disorders. Its pharmacological properties make it an important tool for research into dopamine-related pathways and potential therapeutic interventions. -
Stable Isotope
Ropinirole-d3 hydrochloride is a deuterium-labeled derivative of Ropinirole hydrochloride, functioning as a potent agonist for D2 and D3 dopamine receptors, with a Ki value of 29 nM for the D2 receptor. It exhibits pEC50 values of 7.4, 8.4, and 6.8 for human D2, D3, and D4 receptors, respectively, while showing no affinity for D1 receptors. This compound is primarily utilized in research related to dopamine receptor signaling and has potential implications for therapies targeting Parkinson's disease. -
Dopamine D2 Receptor Antagonist
ADR 851 free base is a potent antagonist of the dopamine D2 receptor, making it valuable for research applications focused on antiemetic effects. This compound demonstrates significant potential in modulating dopamine-related pathways, contributing to the understanding of various neurological and psychiatric disorders. Its utilization in experimental studies may provide insights into therapeutic strategies targeting nausea and vomiting. -
Dopamine Receptor Agonist
Aplindore fumarate is a partial agonist of the dopamine D2 receptor, primarily utilized in neurological research. This compound has shown potential in studies related to Parkinson's disease and schizophrenia, offering insights into dopaminergic signaling pathways. Its activity makes it a valuable tool for investigating therapeutic strategies and understanding the underlying mechanisms of these disorders. -
D3R agonist
7-Hydroxy-PIPAT is a selective agonist of the D3 dopamine receptor, exhibiting a high binding affinity with a Ki value of 0.99 nM. This compound is utilized in research to explore mechanisms related to dopaminergic signaling and may offer insights into the pathology of neuropsychiatric disorders. Its potent activity makes it a valuable tool for studying D3 receptor-mediated pathways in various biological contexts. -
Atypical Dopamine Agonist
S3608 is an atypical dopamine agonist that selectively activates dopamine receptors, contributing to enhanced locomotor activity. This compound has been shown to dose-dependently increase locomotor activity in rodent models, making it a valuable tool for studying dopaminergic signaling and its implications in neuropharmacology. S3608 can be utilized in research applications focused on movement disorders, addiction, and behavioral studies related to dopamine modulation. -
D4 Receptor Antagonist
Sonepiprazole mesylate is a selective D4 dopamine receptor antagonist that exhibits inhibition constants (Kis) of 3.6 nM for rD4-Dopamine and 10.1 nM for hD4.2-Dopamine, indicating potent activity at these targets. Additionally, it shows significantly lower affinity for rD2-Dopamine (5147 nM) and Histamine-H1 receptors (7430 nM). This compound is valuable for research applications focused on neurobiology, particularly in studies related to dopamine receptor signaling and its implications in psychiatric disorders. -
Dopamine Antagonist
Clothixamide is a dopamine antagonist that primarily targets dopamine receptors in the central nervous system. It exhibits biological activity relevant to the modulation of dopaminergic signaling and is useful for investigating various psychiatric disorders, including schizophrenia and depression. Research applications include studying the effects of dopamine inhibition on behavior and neurotransmitter pathways. -
Dopamine Receptor Antagonist
Org-10490 is a potent antagonist of dopamine D1 and D2 receptors, primarily utilized in neurological and psychiatric research. It plays a critical role in studies related to disorders such as schizophrenia and bipolar disorder by modulating dopaminergic signaling pathways. Its efficacy in receptor inhibition makes Org-10490 valuable for investigating therapeutic strategies targeting dopamine-related conditions. -
Dopamine D2 Receptor Antagonist
Lensiprazine is a potent dopamine D2 receptor antagonist that also functions as a serotonin reuptake inhibitor. This compound is primarily utilized in research focusing on psychiatric disorders, including bipolar disorder and schizophrenia, facilitating the exploration of neurochemical pathways involved in these conditions. Its dual action provides valuable insights into the modulation of neurotransmitter systems. -
D2 Dopamine Receptor Blocker
Savoxepin mesylate is a selective antagonist of the D2 dopamine receptor, exhibiting antipsychotic properties. It specifically targets dopamine D2 receptors in the hippocampus while sparing those in the striatum, thereby minimizing the likelihood of extrapyramidal side effects. This selective action makes Savoxepin mesylate a valuable tool for research addressing dopaminergic signaling and its implications in neuropsychiatric disorders. -
D2 Receptor Antagonist
(S)-Remoxipride hydrochloride hydrate is a selective antagonist of the dopamine D2 receptor, exhibiting an IC50 value of 1.57 μM. This compound is primarily utilized in the study of psychotic disorders, providing a valuable tool for understanding the mechanisms underlying dopamine-related pathologies and developing therapeutic strategies. Its specificity for the D2 receptor makes it an important reagent in neuropharmacology research. -
Dopamine Antagonist
Milenperone is a potent dopamine antagonist that primarily targets dopamine receptors. Its biological activity allows for the modulation of dopaminergic signaling, making it valuable in research focusing on neurological disorders. Milenperone is particularly useful in studies investigating the mechanisms underlying conditions related to dopamine dysregulation. -
D2 Receptor Antagonist
Desethoxy Quetiapine dihydrochloride is a selective antagonist of the dopamine D2 receptor, exhibiting an IC50 value of 1330 nM. This compound effectively inhibits Apomorphine-induced climbing and swimming behavior in murine models, making it valuable for investigating neuropharmacological activity and the modulation of dopaminergic signaling. Its utility in behavioral studies supports research into the therapeutic effects of D2 receptor antagonism in psychiatric disorders. -
D4 Receptor Antagonist
Sonepiprazole hydrochloride is a selective antagonist of the D4 dopamine receptor, exhibiting Ki values of 3.6 nM for the rat D4 dopamine receptor and 10.1 nM for the human D4.2 dopamine receptor. This compound demonstrates significant selectivity, with much higher Ki values of 5147 nM and 7430 nM for the rat D2 dopamine and Histamine H1 receptors, respectively. Sonepiprazole hydrochloride is useful for investigating the role of D4 receptors in neurological disorders and may have applications in psychopharmacology research. -
Dopamine D2 Receptor Agonist
FR 64822 is a potent dopamine D2 receptor agonist that demonstrates significant antinociceptive activity in preclinical models, such as rats and mice, via indirect stimulation of these receptors. In addition to its analgesic properties, FR 64822 has been shown to facilitate penile erection in juvenile rats and mitigate scopolamine-induced amnesia during passive avoidance tasks. Its diverse biological activities make it a valuable tool for research in neuropharmacology and behavioral studies. -
D3 Receptor Agonist
(+)-UH 232 is a partially selective agonist of the D3 dopamine receptor, exhibiting an intrinsic activity of 0.2-0.4. This compound effectively antagonizes quinpirole-induced mitogenesis, with a reported Ki value of 9.4 nM. It is utilized in research to explore D3 receptor signaling and its implications in various neurobiological processes. -
Antipsychotic Agent
Butaclamol is an antipsychotic agent that functions primarily as a D2 dopamine receptor antagonist. This compound exhibits significant neuroleptic activity, making it a valuable tool in the study of psychotic disorders. It is utilized in research to explore the mechanisms underlying dopaminergic signaling and its implications in various neuropsychiatric conditions. -
Dopamine Receptor Modulator
Ordopidine hydrochloride is a modulator of dopamine receptors that demonstrates an ED50 of 68 μmol/kg for increasing DOPAC levels in the rat striatum. This compound is valuable in research applications focused on neurological disorders and dopamine-related signaling pathways. Its ability to influence dopamine metabolism makes it a useful tool for exploring the role of dopamine in various physiological and pathological conditions. -
Dopamine Receptor Agonist
PF-592379 is a selective agonist of the dopamine D3 receptor, exhibiting an EC50 of 21 nM. This compound demonstrates significant potential in modulating dopaminergic signaling pathways, making it valuable for research applications related to neuroinflammatory disorders and addiction. Its ability to influence dopamine receptor activity makes PF-592379 a useful tool for studying the role of dopamine in various physiological and pathological processes. -
Dopamine Receptor Antagonist
Benzamide Derivative 1 is a dopamine receptor antagonist with potential applications in the treatment of gastrointestinal disorders. This compound, derived from patent EP0213775A1, compound 18, exhibits key biological activity by modulating dopamine signaling pathways. Its role in gastrointestinal function makes it a valuable tool for researchers investigating the interplay between dopamine receptors and gut health. -
Dopamine Receptor Agonist
U91356 is a selective dopamine receptor agonist that targets D1-like receptors. This compound has been shown to enhance dopaminergic signaling, making it useful in studies investigating neurological disorders such as schizophrenia and Parkinson's disease. U91356 facilitates the exploration of dopamine-related pathways and receptor interactions in various biological systems. -
Endothelin-A Receptor Antagonist
SB 247083 is a selective and competitive antagonist of the endothelin-A receptor, exhibiting a Ki value of 0.41 nM. It displays a significantly lower affinity for the endothelin-B receptor with a Ki of 467 nM. SB 247083 effectively inhibits ET-1-induced contractions in rat aorta, with a Kb of 3.5 nM. This reagent is valuable for research focusing on cardiovascular diseases and their underlying mechanisms. -
Endothelin Receptor Agonist
Sarafotoxin S6a is an endothelin receptor agonist that selectively targets ETA and ETB receptors, exhibiting a profile comparable to Endothelin-3. This compound is known to effectively stimulate vasoconstriction in pig coronary arteries, with an EC50 value of 7.5 nM, making it a valuable tool for studying cardiovascular physiology and pathophysiology. Its targeted interactions facilitate research in vascular biology and related therapeutic areas. -
Endothelin Receptor Antagonist
BMS 182874 is a selective endothelin receptor type A (ETA) antagonist, demonstrating an IC50 value of 0.150 μM and a Ki of 0.055 μM. This compound effectively reduces arterial pressure in models of deoxycorticosterone acetate-induced hypertension in rats, making it a valuable tool for cardiovascular disease research. BMS 182874's targeted action on the endothelin receptor provides insights into vascular function and potential therapeutic approaches for hypertension. -
Endothelin-B Receptor Agonist
Sarafotoxin S6c is a potent agonist of the endothelin-B receptor. This compound induces vasoconstriction in both endothelium-intact and endothelium-denuded vascular tissues, making it a valuable tool for studying endothelial function and vascular tone regulation. Its application in research aids in elucidating the role of endothelin pathways in cardiovascular physiology and pathology.
