Catalog No.
Product Name
Application
Product Information
Citations
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ACTH Fragment
Adrenocorticotropic Hormone (ACTH) (1-10), human, is a fragment of the adrenocorticotropic hormone that primarily regulates the production of cortisol in the adrenal cortex. This peptide exhibits modest α-melanocyte stimulating hormone (α-MSH) activity at elevated concentrations, specifically at 100 and 1000 nM. It is valuable in research applications related to endocrinology and stress response mechanisms, aiding in the understanding of adrenal function and pituitary signaling pathways. -
MC4R Antagonist
(2R,2R)-PF-07258669 is an antagonist of the melanocortin 4 receptor (MC4R). It serves as a valuable tool in research aimed at understanding the regulation of appetite and energy expenditure. Its application can aid in elucidating the role of MC4R in metabolic processes and potential therapeutic interventions for obesity and related disorders. -
Melanocortin Receptor Agonist
(Nle4)-α-MSH is a synthetic analogue of α-MSH and functions as a melanocortin receptor agonist. This compound is known to induce skin darkening in amphibians, specifically frog skins, and demonstrates prolonged biological activity following heat and alkali treatment. It is primarily utilized in studies related to pigmentation, skin biology, and melanocortin signaling pathways. -
α-MSH Analogue
(D-Phe7)-α-MSH is an analogue of α-melanocyte-stimulating hormone (α-MSH), a peptide hormone involved in the regulation of various physiological functions, including pigmentation and appetite control. This compound exhibits biological activity by binding to melanocortin receptors, influencing melanogenesis and potentially modulating inflammatory responses. Research applications include studies on skin pigmentation, obesity, and the role of melanocortin pathways in metabolic processes. -
Antitumor Agent
1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one is an antitumor agent that exhibits significant antiproliferative activity, with effective doses (ED50) of 57.7 μM and 78.8 μM against 26-L5 and HT-1080 cancer cell lines, respectively. Additionally, this compound has been shown to inhibit melanogenesis in B16 melanoma 4A5 cells, indicating its potential utility in studies related to skin disorders and melanoma treatment. Research involving this compound may contribute to the development of therapeutic strategies targeting cancer and pigmentation disorders. -
MC1R Agonist
Dersimelagon phosphate is a selective melanocortin 1 receptor (MC1R) agonist, exhibiting EC50 values of 8.16, 3.91, 1.14, and 0.251 nM for human, cynomolgus monkey, mouse, and rat MC1R, respectively. This compound demonstrates significant affinity for both hMC1R and hMC4R, with Ki values of 2.26 and 32.9 nM, respectively. Dersimelagon phosphate is utilized in research investigating skin pigmentation mechanisms and related biological processes. -
Melanocortin Receptor Agonist
Filimelnotide is a selective agonist of the melanocortin receptors, which are critically involved in various physiological processes including energy homeostasis and skin pigmentation. This compound has demonstrated significant biological activity in modulating appetite, body weight, and metabolic functions. Filimelnotide is particularly relevant for research in obesity, metabolic disorders, and skin-related conditions. -
MC4R Agonist
PF-00446687 hydrochloride is a selective agonist of the melanocortin 4 receptor (MC4R), exhibiting high potency with an EC50 value of 12 nM. This compound demonstrates significant brain penetration, making it suitable for studying neurological pathways. PF-00446687 hydrochloride is primarily utilized in research focused on sexual dysfunction and related metabolic disorders. -
Synthetic ACTH
β-Corticotropin (swine) is a synthetic form of adrenocorticotropic hormone (ACTH), which primarily targets adrenal cortex receptors. This peptide hormone plays a critical role in stimulating the release of steroid hormones, particularly glucocorticoids and mineralocorticoids. It is widely used in research applications focusing on stress response, adrenal function, and metabolic regulation. -
ACTH Fragment
(Phe2,Nle4)-ACTH (1-24) is a synthetic fragment of the adrenocorticotropic hormone (ACTH) that targets the melanocortin receptors. This analog exhibits biological activity relevant to the study of adrenal function and stress response mechanisms. It can be utilized in various research applications, including radiolabeling with I125 at Tyr23 to create a radiolabeled ligand for biochemical assays and receptor binding studies. -
MC4 Receptor Antagonist
HS014 is a selective antagonist of the melanocortin-4 (MC4) receptor, exhibiting a Ki of 3.16 nM for human MC4, while demonstrating significantly lower affinities for MC1, MC3, and MC5 receptors. This compound has been shown to modulate morphine-induced behaviors in murine models, as well as to facilitate increased food intake in free-feeding rat studies. HS014 is a valuable tool in research exploring the regulation of appetite and pain modulation. -
MC3 Receptor Antagonist
PG106 is a selective antagonist of the human melanocortin 3 (hMC3) receptor, exhibiting a potency with an IC50 of 210 nM. The compound demonstrates significant specificity, showing minimal activity at the hMC4 receptor (EC50 of 9900 nM) and no interaction with the hMC5 receptor. Research applications include studies focused on metabolic regulation and potential therapeutic targets related to obesity and related disorders. -
ACTH Fragment
ACTH (4-9) is an adrenocorticotropic hormone (ACTH) fragment that comprises the 4-9 amino acid sequence of the full hormone. This fragment is known to interact with melanocortin receptors, influencing various physiological responses related to stress and immune function. It serves as a valuable tool in research focused on neuroendocrinology, stress response mechanisms, and the development of therapeutic agents targeting melanocortin pathways. -
Melanocortin Receptor Antagonist
MCL-0129 is a selective antagonist of the melanocortin 4 receptor (MC4R), known for its potential anxiolytic and antidepressant properties. This compound exhibits significant anxiolytic and antidepressant-like effects in various rodent models, making it a valuable tool for research into neuropsychiatric disorders. Its specific targeting of MC4R supports studies aimed at elucidating the mechanisms of action in stress-related and mood disorders. -
Melanocortin Receptor Agonist
BMS-470539 is a synthetic agonist of the melanocortin-1 receptor (MC-1R), notable for its potent anti-inflammatory properties. With EC50 values of 16.8 nM and 11.6 nM for human and murine MC-1R activation respectively, it effectively inhibits TNF-alpha-induced NF-kB activation in human melanoma cells. In vivo studies demonstrate that subcutaneous administration of BMS-470539 in BALB/c mice significantly reduces LPS-induced TNF-alpha production, leukocyte infiltration in lung inflammation, and paw swelling in delayed-type hypersensitivity models, indicating its potential as a therapeutic agent targeting inflammation through MC-1R modulation. -
Neuroprotective Agent
ORG 31433 is an orally active peptide that functions as a neuroprotective agent. It is related to the ACTH-(4-9) analog, ORG 2766, and has demonstrated significant neuroprotective effects in various preclinical studies. This compound is valuable for research applications focused on neurodegenerative diseases and neuronal injury. -
α-MSH Inhibitor
Melanostatin, frog is a potent inhibitor of α-melanocyte-stimulating hormone (α-MSH) release, exhibiting an IC50 value of 60 nM. This peptide is primarily utilized in studies investigating melanogenesis and the regulation of pigment production. Its effects on α-MSH make it a valuable tool for research applications focusing on skin biology, obesity, and related metabolic pathways. -
MCR Agonist
Melanotan I acetate is a potent non-selective agonist of melanocortin receptors (MCR). As a synthetic analogue of alpha-melanocyte stimulating hormone (α-MSH), it promotes melanogenesis and induces skin tanning by activating melanocortin type 1 receptors (MC1R) in melanocytes. This compound is valuable for research into the mechanisms of sunlight-induced skin cancers and related photobiological studies. -
ACTH Agonist
Alsactide is a heptadecapeptide analogue that functions as an adrenocorticotropic hormone (ACTH) agonist. This compound is utilized in research focusing on the central nervous system, where it may influence adrenal function and steroidogenesis. Its activity provides valuable insights into neuroendocrine regulation and potential therapeutic applications in disorders related to ACTH signaling. -
Melanogenesis Inhibitor
IIIM-8 is a melanogenesis inhibitor that effectively suppresses pigment production in both in vitro and in vivo models. This compound shows no cytotoxicity in Human Adult Epidermal Melanocytes (HAEM), making it a suitable candidate for research in hyperpigmentation disorders. Its mechanism of action supports studies aimed at understanding melanin synthesis and skin pigmentation regulation. -
Melanocortin Receptor
γ3-MSH is a peptide derived from the N-terminal segment of pro-opiomelanocortin (POMC) that primarily targets melanocortin receptors. It is known to stimulate aldosterone secretion in human adrenal tumor cells in vitro, making it a valuable tool for research into adrenal function and pathophysiology. This compound can be utilized in studies aimed at understanding the regulatory mechanisms of hormone secretion and the role of melanocortin signaling in adrenal tumors. -
MC3R/MC4R Agonist
α-MSH free acid is a potent agonist of the melanocortin receptors MC3R and MC4R, exhibiting EC50 values of 0.16 nM and 5.6 nM, respectively. This compound stimulates cAMP production upon receptor activation, making it a valuable tool for research in metabolic regulation, appetite control, and neurobiology. Its effects on signaling pathways also support its use in studying obesity and related disorders. -
Melanocortin Agonist
JLB2-110c is a potent melanocortin receptor agonist, specifically targeting the melanocortin-4 receptor (MC4R) with an EC50 of 0.34 nM. This compound demonstrates significant appetite suppressant effects in vivo, making it a valuable tool for research into obesity and metabolic disorders. Its ability to modulate energy homeostasis positions JLB2-110c as a key reagent for studies related to appetite regulation and weight management. -
Melanocortin Receptor Antagonist
(p-Iodo-Phe7)-ACTH (4-10) is a derivative of adrenocorticotrophic hormone (ACTH) that functions as a melanocortin receptor antagonist. This compound effectively inhibits the action of α-melanocyte-stimulating hormone (α-MSH), thereby reducing excessive grooming behavior observed in rat models. It serves as a valuable tool in research focused on the modulation of melanocortin signaling pathways and behaviors influenced by the central nervous system. -
Melanocortin 4 Receptor Agonist
RO27-3225 is a potent and selective agonist of the melanocortin 4 receptor (MC4R), exhibiting an EC50 of 1 nM for MC4R and 8 nM for MC1R, demonstrating a 30-fold selectivity for MC4R over MC3R. This compound shows significant neuroprotective and anti-inflammatory effects, making it valuable for research in metabolic disorders, obesity, and neurodegenerative diseases. Its specific action on MC4R positions RO27-3225 as a key reagent for exploring the therapeutic potential of melanocortin signaling pathways. -
Melanocortin Receptor Inhibitor
Chlorophorin is an inhibitor of the Melanocortin Receptor, effectively reducing tyrosinase activity and melanogenesis. This compound demonstrates significant inhibition of α-melanocyte-stimulating hormone-induced melanin production in B16F10 melanoma cells, making it valuable for research on pigmentation disorders and melanoma. Its mechanism of action provides insights into the modulation of skin pigmentation and potential therapeutic strategies. -
Melanocortin Receptor Agonist
ACTH (1-17) is a potent agonist of the human melanocortin 1 (MC1) receptor, exhibiting a Ki of 0.21 nM. This adrenocorticotropin analogue plays a critical role in modulating melanogenesis and has significant implications for research in skin pigmentation and endocrine regulation. Its efficacy makes it a valuable tool for studies focused on melanocortin signaling pathways and related therapeutic applications. -
MC4R Agonist
RY764 is a selective agonist for the melanocortin-4 receptor (MC4R), demonstrating an EC50 of 10 nM. This compound effectively reduces food intake and mitigates body weight gain in diet-induced obese (DIO) rat models. RY764 is suitable for research applications focusing on obesity and metabolic disorders. -
Melanogenesis Inhibitor
(R)-Lirinidine is an aporphine-type alkaloid derived from Nelumbo nucifera, known for its role as a melanogenesis inhibitor. With an IC50 value of 19.3 μM, it effectively reduces melanin production, making it valuable for research in skin pigmentation disorders. Additionally, (R)-Lirinidine exhibits cytotoxic effects at concentrations of 100 μM, highlighting its potential in various biological studies. -
Amino-terminal Fragment of AGRP
Agouti-Related Protein (54-82) (human) is an amino-terminal fragment of the agouti-related protein (AGRP), specifically spanning residues 54 to 82. This peptide plays a critical role in the regulation of appetite and energy homeostasis by acting as an antagonist of the melanocortin receptors. It is widely utilized in research examining metabolic disorders, obesity, and neuroendocrine signaling pathways. -
MC4R Agonist
MK-0489 is a selective agonist targeting the melanocortin-4 receptor (MC4R). Demonstrating a strong binding affinity with an IC50 of 13 nM and functional activity characterized by an EC50 of 4.6 nM in human MC4R, it also exhibits an EC50 of 22 nM for mouse MC4R and 1.7 μM for mouse MC3R. This compound is valuable for research applications focused on obesity and related metabolic disorders. -
ACTH Analogue
ACTH (3-24) is a peptide fragment of adrenocorticotropic hormone (ACTH) consisting of residues 3-24. This ACTH analogue plays a critical role in modulating adrenal steroidogenesis and has been utilized in research focused on various diseases, including cancer, immune disorders, and cardiovascular diseases. Its ability to influence hormone release makes it valuable for studying endocrine function and related pathologies across different species, including human, bovine, and rodent models. -
MC4R Agonist
Bivamelagon hydrochloride is a potent agonist of the melanocortin 4 receptor (MC4R), demonstrating EC50 values of 0.562 nM in luciferase assays and 36.5 nM in cAMP assays, along with a Ki of 65 nM. This compound exhibits oral bioavailability and the ability to cross the blood-brain barrier, making it a valuable tool in research focused on metabolic disorders, particularly obesity and diabetes. Bivamelagon hydrochloride facilitates the exploration of MC4R signaling pathways and their implications in metabolic regulation. -
hMC5R Antagonist
Ac-c[Cys-Glu-His-d-Phe-Arg-Trp-d-Cys]-Pro-Pro-Lys-Asp-NH2 is a selective antagonist of the human melanocortin 5 receptor (hMC5R), exhibiting an IC50 value of 10 nM. This compound is crucial for studies focusing on hMC5R-related signaling pathways and their implications in various physiological processes. Its specificity makes it a valuable tool for investigating the role of hMC5R in metabolic regulation and other biological functions. -
Melanogenesis Inhibitor
Amphistin is a melanogenesis inhibitor derived from actinomycetes. It effectively suppresses melanin production in B16 melanoma cells while demonstrating no significant impact on cellular growth. This compound is of interest for research applications focused on hyperpigmentation disorders and skin-related studies. -
Melanogenesis Inhibitor
Albocycline K3 acts as a melanogenesis inhibitor and is derived from microbial sources. This compound effectively reduces melanin production, making it suitable for research in skin biology and pigmentation disorders. Its unique mechanism of action provides valuable insights into the modulation of melanin synthesis and may aid in the development of therapies for conditions such as hyperpigmentation. -
Melanin Biosynthesis Inhibitor
Melanocin A is a potent melanin biosynthesis inhibitor that specifically targets tyrosinase, demonstrating an IC50 of 9.0 nM and a MIC of 0.9 μM. This compound effectively reduces melanin production and exhibits antioxidant properties, making it valuable for research into skin pigmentation disorders and oxidative stress-related conditions. Melanocin A can be utilized in studies examining the regulation of melanogenesis and potential therapeutic approaches for hyperpigmentation. -
ACTH Inhibitor
Delmadinone acetate is an orally active ACTH inhibitor that exerts its effects by suppressing adrenal function through the inhibition of adrenocorticotropic hormone release from the pituitary gland. This compound is primarily used in veterinary medicine for the control of estrus and ovulation in both female and male pets. Its ability to modulate endocrine functions makes it valuable for research focused on reproductive biology and hormonal regulation. -
Melanin Biosynthesis Inhibitor
Melanoxazal is an inhibitor of melanin biosynthesis. It effectively reduces melanin formation in silkworm larva hemolymph, with an IC50 of 30.1 μg/mL, and demonstrates a potent inhibitory effect on mushroom tyrosinase, exhibiting an IC50 of 4.2 μg/mL. This compound is primarily utilized in research exploring pigmentation processes and the role of melanin in various biological systems. -
MC4R Antagonist
MPCI is a selective antagonist of the melanocortin-4 receptor (MC4R), exhibiting pharmacological chaperone activity. With a Ki value of 0.218 μM determined in HEK293 cells expressing human MC4R, MPCI is valuable in researching the mechanisms underlying MC4R-deficient obesity. This compound can facilitate studies on metabolic regulation and potential therapeutic approaches for related disorders. -
Melanocortin Receptor Agonist
MC-4R Agonist 1 is a selective agonist of the human melanocortin-4 receptor (MC-4R), known for its role in regulating energy homeostasis and appetite. This compound has demonstrated significant biological activity in research focusing on obesity, diabetes, and sexual dysfunction, making it a valuable tool for studies exploring metabolic pathways and associated disorders. Its use in scientific investigations may provide insights into potential therapeutic approaches for these conditions.
