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Form	MW
BMS-470539 This page	559.70
BMS-470539 dihydrochloride	632.62

BMS-470539

Melanocortin Receptor Agonist

BMS-470539 is a synthetic agonist of the melanocortin-1 receptor (MC-1R), notable for its potent anti-inflammatory properties. With EC50 values of 16.8 nM and 11.6 nM for human and murine MC-1R activation respectively, it effectively inhibits TNF-alpha-induced NF-kB activation in human melanoma cells. In vivo studies demonstrate that subcutaneous administration of BMS-470539 in BALB/c mice significantly reduces LPS-induced TNF-alpha production, leukocyte infiltration in lung inflammation, and paw swelling in delayed-type hypersensitivity models, indicating its potential as a therapeutic agent targeting inflammation through MC-1R modulation.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Agonist
CAS Number	457893-92-4
Applications	Melanocortin Receptor Agonist
Formula	C₃₂H₄₁N₅O₄
Molecular Weight	559.70
SMILES	CCCC(C1(C2=CC=CC=C2)CCN(C([C@@H](CC3=CC=C(C=C3)OC)NC([C@H](CC4=CN=CN4C)N)=O)=O)CC1)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.