HS014

Name: HS014
Brand: Adooq Bioscience
SKU: A61677
Rating: 5 (288 reviews)

Catalog No.: A61677

MC4 Receptor Antagonist

HS014 is a selective antagonist of the melanocortin-4 (MC4) receptor, exhibiting a Ki of 3.16 nM for human MC4, while demonstrating significantly lower affinities for MC1, MC3, and MC5 receptors. This compound has been shown to modulate morphine-induced behaviors in murine models, as well as to facilitate increased food intake in free-feeding rat studies. HS014 is a valuable tool in research exploring the regulation of appetite and pain modulation.

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HS014 207678-81-7 MC4 Receptor Antagonist

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Size	Price	Stock	Qty
1mg	$335.00	In stock
Bulk Size	Bulk Discount

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Data Sheet SDS

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Biological Activity

Description

Product Information

Catalog Num	A61677
Formula	C71H94N20O17S2
Molecular Weight	1563.76
CAS Number	207678-81-7
Sequence	Ac-Cys-Glu-His-{D-2Nal}-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asp-NH2 (Disulfide bridge:Cys1-Cys8)
Sequence shortening	Ac-CEH-{D-2Nal}-RWGCPPKD-NH2 (Disulfide bridge:Cys1-Cys8)
SMILES	C(C=1C=2C(NC1)=CC=CC2)[C@@H]3NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](CC4=CC5=C(C=C4)C=CC=C5)NC(=O)[C@H](CC6=CN=CN6)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(C)=O)CSSC[C@@H](C(=O)N7[C@H](C(=O)N8[C@H](C(N[C@H](C(N[C@@H](CC(O)=O)C(N)=O)=O)CCCCN)=O)CCC8)CCC7)NC(=O)CNC3=O

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