Fig. 1 · Structure
Documents & Downloads
PF-00446687 hydrochloride
MC4R Agonist
PF-00446687 hydrochloride is a selective agonist of the melanocortin 4 receptor (MC4R), exhibiting high potency with an EC50 value of 12 nM. This compound demonstrates significant brain penetration, making it suitable for studying neurological pathways. PF-00446687 hydrochloride is primarily utilized in research focused on sexual dysfunction and related metabolic disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 862282-10-8 |
| Applications | MC4R Agonist |
| Formula | C28H37ClF2N2O2 |
| Molecular Weight | 507.06 |
| SMILES | O=C(N1C[C@H]([C@@]([C@H](C1)C)(C2=CC=CC=C2)O)C)[C@H]3[C@H](C4=C(C=C(C=C4)F)F)CN(C3)C(C)(C)C.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.