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(p-Iodo-Phe7)-ACTH (4-10)

Melanocortin Receptor Antagonist

(p-Iodo-Phe7)-ACTH (4-10) is a derivative of adrenocorticotrophic hormone (ACTH) that functions as a melanocortin receptor antagonist. This compound effectively inhibits the action of α-melanocyte-stimulating hormone (α-MSH), thereby reducing excessive grooming behavior observed in rat models. It serves as a valuable tool in research focused on the modulation of melanocortin signaling pathways and behaviors influenced by the central nervous system.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	159600-82-5
Applications	Melanocortin Receptor Antagonist
Formula	C₄₄H₅₈IN₁₃O₁₀S
Molecular Weight	1087.98
SMILES	C([C@H](NC([C@@H](NC([C@H](CC1=CC=C(I)C=C1)NC([C@H](CC2=CN=CN2)NC([C@@H](NC([C@H](CCSC)N)=O)CCC(O)=O)=O)=O)=O)CCCNC(=N)N)=O)C(NCC(O)=O)=O)C=3C=4C(NC3)=CC=CC4

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.