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RO27-3225

Catalog No.: A61694
Melanocortin 4 Receptor Agonist
RO27-3225 is a potent and selective agonist of the melanocortin 4 receptor (MC4R), exhibiting an EC50 of 1 nM for MC4R and 8 nM for MC1R, demonstrating a 30-fold selectivity for MC4R over MC3R. This compound shows significant neuroprotective and anti-inflammatory effects, making it valuable for research in metabolic disorders, obesity, and neurodegenerative diseases. Its specific action on MC4R positions RO27-3225 as a key reagent for exploring the therapeutic potential of melanocortin signaling pathways.
RO27-3225 274682-89-2 Melanocortin 4 Receptor Agonist
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionRO27-3225 is a potent and selective agonist of the melanocortin 4 receptor (MC4R), exhibiting an EC50 of 1 nM for MC4R and 8 nM for MC1R, demonstrating a 30-fold selectivity for MC4R over MC3R. This compound shows significant neuroprotective and anti-inflammatory effects, making it valuable for research in metabolic disorders, obesity, and neurodegenerative diseases. Its specific action on MC4R positions RO27-3225 as a key reagent for exploring the therapeutic potential of melanocortin signaling pathways.
Product Information
Catalog NumA61694
FormulaC39H52N12O6
Molecular Weight784.91
CAS Number274682-89-2
Sequence{Butir}-His-{dPhe}-Arg-Trp-{Sar}-NH2
Sequence shortening{Butir}-H-{dPhe}-RW-{Sar}-NH2
SMILESC([C@H](NC([C@@H](NC([C@@H](CC1=CC=CC=C1)NC([C@H](CC2=CN=CN2)NC(CCC)=O)=O)=O)CCCNC(=N)N)=O)C(N(CC(N)=O)C)=O)C=3C=4C(NC3)=CC=CC4
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GPCR/G Protein > Melanocortin Receptor