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RO27-3225

Melanocortin 4 Receptor Agonist

RO27-3225 is a potent and selective agonist of the melanocortin 4 receptor (MC4R), exhibiting an EC50 of 1 nM for MC4R and 8 nM for MC1R, demonstrating a 30-fold selectivity for MC4R over MC3R. This compound shows significant neuroprotective and anti-inflammatory effects, making it valuable for research in metabolic disorders, obesity, and neurodegenerative diseases. Its specific action on MC4R positions RO27-3225 as a key reagent for exploring the therapeutic potential of melanocortin signaling pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Agonist
CAS Number	274682-89-2
Applications	Melanocortin 4 Receptor Agonist
Formula	C₃₉H₅₂N₁₂O₆
Molecular Weight	784.91
SMILES	C([C@H](NC([C@@H](NC([C@@H](CC1=CC=CC=C1)NC([C@H](CC2=CN=CN2)NC(CCC)=O)=O)=O)CCCNC(=N)N)=O)C(N(CC(N)=O)C)=O)C=3C=4C(NC3)=CC=CC4

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.