Bivamelagon hydrochloride is a potent agonist of the melanocortin 4 receptor (MC4R), demonstrating EC50 values of 0.562 nM in luciferase assays and 36.5 nM in cAMP assays, along with a Ki of 65 nM. This compound exhibits oral bioavailability and the ability to cross the blood-brain barrier, making it a valuable tool in research focused on metabolic disorders, particularly obesity and diabetes. Bivamelagon hydrochloride facilitates the exploration of MC4R signaling pathways and their implications in metabolic regulation.
Bivamelagon hydrochloride is a potent agonist of the melanocortin 4 receptor (MC4R), demonstrating EC50 values of 0.562 nM in luciferase assays and 36.5 nM in cAMP assays, along with a Ki of 65 nM. This compound exhibits oral bioavailability and the ability to cross the blood-brain barrier, making it a valuable tool in research focused on metabolic disorders, particularly obesity and diabetes. Bivamelagon hydrochloride facilitates the exploration of MC4R signaling pathways and their implications in metabolic regulation.
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