Fig. 1 · Structure
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Bivamelagon hydrochloride
MC4R Agonist
Bivamelagon hydrochloride is a potent agonist of the melanocortin 4 receptor (MC4R), demonstrating EC50 values of 0.562 nM in luciferase assays and 36.5 nM in cAMP assays, along with a Ki of 65 nM. This compound exhibits oral bioavailability and the ability to cross the blood-brain barrier, making it a valuable tool in research focused on metabolic disorders, particularly obesity and diabetes. Bivamelagon hydrochloride facilitates the exploration of MC4R signaling pathways and their implications in metabolic regulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 2641595-55-1 |
| Applications | MC4R Agonist |
| Formula | C35H54Cl2N4O4 |
| Molecular Weight | 665.73 |
| Synonyms | MC-4R Agonist 2 hydrochloride |
| SMILES | O=C([C@H]1[C@H](C2=CC=C(C=C2)Cl)CN(C1)C(C)(C)C)N3[C@@H](C[C@@H](C3)N([C@@H]4CC[C@@H](CC4)C)C(C(C)C)=O)C(N5CCOCC5)=O.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.