Custirsen is a targeted antisense oligonucleotide that inhibits the expression of clusterin, an antiapoptotic protein often upregulated in response to chemotherapy. By downregulating clusterin, custirsen enhances apoptosis in cancer cells, thereby overcoming treatment resistance. This compound is primarily utilized in cancer research, particularly in studies focused on improving therapeutic efficacy and understanding apoptotic mechanisms in tumor biology.
Custirsen is a targeted antisense oligonucleotide that inhibits the expression of clusterin, an antiapoptotic protein often upregulated in response to chemotherapy. By downregulating clusterin, custirsen enhances apoptosis in cancer cells, thereby overcoming treatment resistance. This compound is primarily utilized in cancer research, particularly in studies focused on improving therapeutic efficacy and understanding apoptotic mechanisms in tumor biology.
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