Fig. 1 · Structure
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CRT0066101 trihydrochloride
PKD Inhibitor
CRT0066101 trihydrochloride is a potent inhibitor of Protein Kinase D (PKD), exhibiting IC50 values of 1 nM, 2.5 nM, and 2 nM against PKD1, PKD2, and PKD3, respectively. In addition to its PKD-inhibitory properties, it also targets PIM2 with an IC50 of approximately 135.7 nM. This compound demonstrates significant anti-inflammatory effects in lipopolysaccharide (LPS)-induced lung injury models in mice and exhibits potential anticancer activity, making it a valuable reagent for research in oncology and inflammation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1781742-22-0 |
| Applications | PKD Inhibitor |
| Formula | C18H25Cl3N6O |
| Molecular Weight | 447.79 |
| SMILES | [H]Cl.[H]Cl.[H]Cl.N[C@H](CC)CNC1=NC(C2=C(O)C=CC(C3=CN(C)N=C3)=C2)=NC=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.