Astemizole-d3 is a deuterium-labeled derivative of Astemizole, a second-generation antihistamine primarily functioning as a histamine H1-receptor antagonist, exhibiting an IC50 of 4 nM. This compound is not only effective in alleviating allergic symptoms but also possesses significant hERG K+ channel blocking activity, with an IC50 of 0.9 nM. Astemizole-d3 is valuable in pharmacokinetic studies and drug metabolism research, providing a stable isotope for tracing and quantitative analysis in biological systems.
Astemizole-d3 is a deuterium-labeled derivative of Astemizole, a second-generation antihistamine primarily functioning as a histamine H1-receptor antagonist, exhibiting an IC50 of 4 nM. This compound is not only effective in alleviating allergic symptoms but also possesses significant hERG K+ channel blocking activity, with an IC50 of 0.9 nM. Astemizole-d3 is valuable in pharmacokinetic studies and drug metabolism research, providing a stable isotope for tracing and quantitative analysis in biological systems.
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