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Mitotane-d8

Stable Isotope

Mitotane-d8 is a deuterated form of Mitotane, an antineoplastic agent predominantly used in the study of adrenocortical carcinoma. Mitotane exerts its adrenocorticolytic effects, in part, through inducing lipotoxicity via intracellular accumulation of free cholesterol. Additionally, it influences pituitary function by directly acting on corticotroph cells and activates CYP3A4 gene expression through the steroid and xenobiotic receptor (SXR). This stable isotope is valuable for pharmacokinetic studies and metabolic profiling in cancer research.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2673270-14-7
Applications	Stable Isotope
Formula	C₁₄H₂D₈Cl₄
Molecular Weight	328.09
Synonyms	2,4′-DDD-d8; o,p'-DDD-d8
SMILES	ClC(Cl)C(C1=C([2H])C([2H])=C(C([2H])=C1[2H])Cl)C2=C(C([2H])=C([2H])C([2H])=C2[2H])Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.