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Licofelone-d6

Stable Isotope

Licofelone-d6 is a deuterium-labeled derivative of Licofelone, a dual inhibitor of cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) with IC50 values of 0.21 µM and 0.18 µM, respectively. This compound demonstrates significant anti-inflammatory and anti-proliferative properties, making it relevant for research in osteoarthritis treatments. Licofelone-induced apoptosis and its ability to reduce the production of proinflammatory leukotrienes and prostaglandins further underscore its potential as a valuable tool in chemical biology.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	1178549-81-9
Applications	Stable Isotope
Formula	C₂₃H₁₆D₆ClNO₂
Molecular Weight	385.92
Synonyms	ML-3000-d6
SMILES	OC(CC1=C(C2=CC=C(C=C2)Cl)C(C3=CC=CC=C3)=C4N1CC(C([2H])([2H])[2H])(C4)C([2H])([2H])[2H])=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.