Fig. 1 · Structure
Documents & Downloads
Metformin-d6
Stable Isotope
Metformin-d6 (1,1-Dimethylbiguanide-d6) serves as a stable isotope-labeled version of Metformin, which primarily targets the mitochondrial respiratory chain in the liver. This compound is critical for studies on type 2 diabetes management due to its role in activating AMPK, thus enhancing insulin sensitivity. Additionally, Metformin-d6 contributes to understanding glucose regulation through the inhibition of Rap1 in SF1 hypothalamic neurons. Its utility extends to investigating liver oxidative stress and the modulation of autophagy-related proteins via AMPK activation and mTOR inhibition, making it relevant for evaluating renal cell carcinoma growth in both in vitro and in vivo settings.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1185512-92-8 |
| Applications | Stable Isotope |
| Formula | C4H5D6N5 |
| Molecular Weight | 135.20 |
| Synonyms | 1,1-Dimethylbiguanide-d6 |
| SMILES | N=C(N)NC(N(C([2H])([2H])[2H])C([2H])([2H])[2H])=N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.