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Radotinib-d6

Stable Isotope

Radotinib-d6 is a deuterium-labeled form of Radotinib, a selective inhibitor of the Bcr-Abl1 tyrosine kinase, recognized for its ability to penetrate the blood-brain barrier. With an IC50 of 34 nM, Radotinib exhibits significant anti-tumor activity, inhibiting cellular proliferation and inducing cell cycle arrest and apoptosis in tumor cells. This reagent is particularly valuable for research focused on chronic myeloid leukemia, multiple myeloma, and neurodegenerative conditions, including prion diseases.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2754051-83-5
Applications	Stable Isotope
Formula	C₂₇H₁₅D₆F₃N₈O
Molecular Weight	536.54
Synonyms	IY-5511-d6
SMILES	O=C(NC1=CC(C(F)(F)F)=CC(N2C=C(C)N=C2)=C1)C3=C([2H])C([2H])=C(C([2H])([2H])[2H])C(NC4=NC=CC(C5=NC=CN=C5)=N4)=C3[2H]

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.