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2-Methoxyestradiol-13C,d3

Stable Isotope

2-Methoxyestradiol-13C,d3 is a stable isotope-labeled version of 2-Methoxyestradiol, an endogenous metabolite of 17β-estradiol. It functions primarily as an apoptosis inducer and angiogenesis inhibitor, demonstrating significant antineoplastic properties. Additionally, 2-Methoxyestradiol destabilizes microtubules and acts as a potent inhibitor of superoxide dismutase (SOD), generating reactive oxygen species (ROS) that can induce autophagy in various cancer cell lines such as HEK293, U87, and HeLa. This reagent is valuable for research in cancer biology and the mechanisms of estrogen metabolism.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	1217470-09-1
Applications	Stable Isotope
Formula	C₁₈₁₃CH₂₃D₃O₃
Molecular Weight	306.42
SMILES	C[C@@]12[C@](CC[C@@H]2O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC(O[13C]([2H])([2H])[2H])=C(O)C=C4CC3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.