2-Methoxyestradiol-13C,d3 is a stable isotope-labeled version of 2-Methoxyestradiol, an endogenous metabolite of 17β-estradiol. It functions primarily as an apoptosis inducer and angiogenesis inhibitor, demonstrating significant antineoplastic properties. Additionally, 2-Methoxyestradiol destabilizes microtubules and acts as a potent inhibitor of superoxide dismutase (SOD), generating reactive oxygen species (ROS) that can induce autophagy in various cancer cell lines such as HEK293, U87, and HeLa. This reagent is valuable for research in cancer biology and the mechanisms of estrogen metabolism.
2-Methoxyestradiol-13C,d3 is a stable isotope-labeled version of 2-Methoxyestradiol, an endogenous metabolite of 17β-estradiol. It functions primarily as an apoptosis inducer and angiogenesis inhibitor, demonstrating significant antineoplastic properties. Additionally, 2-Methoxyestradiol destabilizes microtubules and acts as a potent inhibitor of superoxide dismutase (SOD), generating reactive oxygen species (ROS) that can induce autophagy in various cancer cell lines such as HEK293, U87, and HeLa. This reagent is valuable for research in cancer biology and the mechanisms of estrogen metabolism.
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