Trametinib-13C,d3

Catalog No.: A32809
Stable Isotope
Trametinib-13C,d3 is a stable isotope-labeled analog of Trametinib, a potent MEK1 and MEK2 inhibitor. With an IC50 of approximately 2 nM, Trametinib is known to activate autophagy and induce apoptosis in various cellular models. This labeled compound is ideal for use in metabolic studies, pharmacokinetic research, and tracer studies involving MEK signaling pathways.
Grouped product items
Size Price Stock Qty
1mg
$745.00
In stock
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionTrametinib-13C,d3 is a stable isotope-labeled analog of Trametinib, a potent MEK1 and MEK2 inhibitor. With an IC50 of approximately 2 nM, Trametinib is known to activate autophagy and induce apoptosis in various cellular models. This labeled compound is ideal for use in metabolic studies, pharmacokinetic research, and tracer studies involving MEK signaling pathways.
Product Information
Catalog NumA32809
FormulaC2513CH20D3FIN5O4
Molecular Weight619.41
CAS Number2712126-59-3
SMILESCC(NC1=CC=CC(N(C(C(C(N2C3CC3)=O)=C(NC4=CC=C(I)C=C4F)N5C)=C([13C]([2H])([2H])[2H])C5=O)C2=O)=C1)=O
SynonymsGSK1120212-13C,d3; JTP-74057-13C,d3
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