Fig. 1 · Structure
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Trametinib-13C,d3
Stable Isotope
Trametinib-13C,d3 is a stable isotope-labeled analog of Trametinib, a potent MEK1 and MEK2 inhibitor. With an IC50 of approximately 2 nM, Trametinib is known to activate autophagy and induce apoptosis in various cellular models. This labeled compound is ideal for use in metabolic studies, pharmacokinetic research, and tracer studies involving MEK signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2712126-59-3 |
| Applications | Stable Isotope |
| Formula | C2513CH20D3FIN5O4 |
| Molecular Weight | 619.41 |
| Synonyms | GSK1120212-13C,d3; JTP-74057-13C,d3 |
| SMILES | CC(NC1=CC=CC(N(C(C(C(N2C3CC3)=O)=C(NC4=CC=C(I)C=C4F)N5C)=C([13C]([2H])([2H])[2H])C5=O)C2=O)=C1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.