Fig. 1 · Structure
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Dapivirine-d11
Stable Isotope
Dapivirine-d11 is a deuterium-labeled derivative of Dapivirine, a nonnucleoside reverse transcriptase inhibitor (NRTI) that specifically targets HIV-1 reverse transcriptase. This stable isotope-labeled compound is utilized in research to investigate the metabolic pathways and pharmacokinetics of Dapivirine. Additionally, Dapivirine has been shown to modulate autophagy and activate key signaling molecules such as Akt, Bad, and SAPK/JNK, making it relevant for studies in HIV therapy and cellular response mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1329613-10-6 |
| Applications | Stable Isotope |
| Formula | C20H8D11N5 |
| Molecular Weight | 340.47 |
| Synonyms | TMC120-d11; R147681-d11 |
| SMILES | N#CC1=CC=C(NC2=NC=CC(NC3=C(C([2H])([2H])[2H])C([2H])=C(C([2H])([2H])[2H])C([2H])=C3C([2H])([2H])[2H])=N2)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.