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Mitotane-13C12

Stable Isotope

Mitotane-13C12 (2,4′-DDD-13C12) is a stable isotope-labeled form of Mitotane, an antineoplastic agent primarily utilized in the study of adrenocortical carcinoma. This compound exerts its adrenocorticolytic effects through mechanisms involving lipotoxicity and the accumulation of intracellular free cholesterol. Additionally, Mitotane influences endocrine functions by affecting corticotroph cells in the pituitary and induces CYP3A4 gene expression via activation of the steroid and xenobiotic receptor (SXR). This reagent is valuable for metabolic and pharmacokinetic studies in cancer research.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2483736-36-1
Applications	Stable Isotope
Formula	C₂₁₃C₁₂H₁₀Cl₄
Molecular Weight	331.95
Synonyms	2,4′-DDD-13C12; o,p'-DDD-13C12
SMILES	ClC(Cl)C([13C]1=[13CH][13CH]=[13C]([13CH]=[13CH]1)Cl)[13C]2=[13C]([13CH]=[13CH][13CH]=[13CH]2)Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.