Mitotane-13C12 (2,4′-DDD-13C12) is a stable isotope-labeled form of Mitotane, an antineoplastic agent primarily utilized in the study of adrenocortical carcinoma. This compound exerts its adrenocorticolytic effects through mechanisms involving lipotoxicity and the accumulation of intracellular free cholesterol. Additionally, Mitotane influences endocrine functions by affecting corticotroph cells in the pituitary and induces CYP3A4 gene expression via activation of the steroid and xenobiotic receptor (SXR). This reagent is valuable for metabolic and pharmacokinetic studies in cancer research.
Mitotane-13C12 (2,4′-DDD-13C12) is a stable isotope-labeled form of Mitotane, an antineoplastic agent primarily utilized in the study of adrenocortical carcinoma. This compound exerts its adrenocorticolytic effects through mechanisms involving lipotoxicity and the accumulation of intracellular free cholesterol. Additionally, Mitotane influences endocrine functions by affecting corticotroph cells in the pituitary and induces CYP3A4 gene expression via activation of the steroid and xenobiotic receptor (SXR). This reagent is valuable for metabolic and pharmacokinetic studies in cancer research.
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