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Dapivirine-d4

Stable Isotope

Dapivirine-d4 is a deuterium-labeled analog of Dapivirine, a nonnucleoside reverse transcriptase inhibitor (NRTI) that targets HIV-1 reverse transcriptase. This compound serves as a stable isotope for various analytical applications, enhancing the study of Dapivirine metabolism and pharmacokinetics. Dapivirine demonstrates biological activities such as autophagy regulation and activation of signaling pathways, including Akt, Bad, and SAPK/JNK, making it relevant for research into HIV-1 treatment and cellular responses.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	1309283-15-5
Applications	Stable Isotope
Formula	C₂₀H₁₅D₄N₅
Molecular Weight	333.42
Synonyms	TMC120-d4; R147681-d4
SMILES	N#CC1=C([2H])C([2H])=C(NC2=NC=CC(NC3=C(C)C=C(C)C=C3C)=N2)C([2H])=C1[2H]

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.