AAK1-IN-8 is a selective inhibitor of AAK1 and GAK, demonstrating effective inhibition with EC50 values of 50 nM and 190 nM, respectively. This compound significantly hinders the phosphorylation of the AP2-µ2 subunit at threonine 156, providing insight into clathrin-mediated endocytosis. AAK1-IN-8 is utilized in research applications focused on uncovering the roles of AAK1 and GAK in cellular processes and their implications in diseases related to endocytic pathways.
AAK1-IN-8 is a selective inhibitor of AAK1 and GAK, demonstrating effective inhibition with EC50 values of 50 nM and 190 nM, respectively. This compound significantly hinders the phosphorylation of the AP2-µ2 subunit at threonine 156, providing insight into clathrin-mediated endocytosis. AAK1-IN-8 is utilized in research applications focused on uncovering the roles of AAK1 and GAK in cellular processes and their implications in diseases related to endocytic pathways.
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