Facinicline hydrochloride is a selective partial agonist of the nicotinic α7 acetylcholine receptor (nAChR), exhibiting a Ki of 6 nM. This compound has demonstrated potential in enhancing cognitive function and sensorimotor gating in rodent models, making it a valuable tool for research on cognitive disorders. Additionally, Facinicline hydrochloride shows high affinity as an antagonist at the 5-HT3 receptor, with a Ki of 1.2 nM, widening its applicability in neurological and psychiatric research.
Facinicline hydrochloride is a selective partial agonist of the nicotinic α7 acetylcholine receptor (nAChR), exhibiting a Ki of 6 nM. This compound has demonstrated potential in enhancing cognitive function and sensorimotor gating in rodent models, making it a valuable tool for research on cognitive disorders. Additionally, Facinicline hydrochloride shows high affinity as an antagonist at the 5-HT3 receptor, with a Ki of 1.2 nM, widening its applicability in neurological and psychiatric research.
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