NS-6740 is a partial agonist of the α7 nicotinic acetylcholine receptor (α7 nAChR), exhibiting an IC50 of 3 nM. This compound functions as a potent modulator of the cholinergic anti-inflammatory pathway, influencing α7 signaling in an ion channel-independent manner, which ultimately reduces synaptic function. NS-6740 promotes the desensitized state of α7 nAChR and elicits substantial nAChR-mediated currents. It is effective in decreasing LPS-induced TNF-α release from microglia, making it a valuable tool for research into neuroinflammation and neuropathic pain mechanisms.
NS-6740 is a partial agonist of the α7 nicotinic acetylcholine receptor (α7 nAChR), exhibiting an IC50 of 3 nM. This compound functions as a potent modulator of the cholinergic anti-inflammatory pathway, influencing α7 signaling in an ion channel-independent manner, which ultimately reduces synaptic function. NS-6740 promotes the desensitized state of α7 nAChR and elicits substantial nAChR-mediated currents. It is effective in decreasing LPS-induced TNF-α release from microglia, making it a valuable tool for research into neuroinflammation and neuropathic pain mechanisms.
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