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NS-6740

α7 nAChR Agonist

NS-6740 is a partial agonist of the α7 nicotinic acetylcholine receptor (α7 nAChR), exhibiting an IC50 of 3 nM. This compound functions as a potent modulator of the cholinergic anti-inflammatory pathway, influencing α7 signaling in an ion channel-independent manner, which ultimately reduces synaptic function. NS-6740 promotes the desensitized state of α7 nAChR and elicits substantial nAChR-mediated currents. It is effective in decreasing LPS-induced TNF-α release from microglia, making it a valuable tool for research into neuroinflammation and neuropathic pain mechanisms.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Partial Agonist
CAS Number	753500-02-6
Applications	α7 nAChR Agonist
Formula	C₁₉H₁₉F₃N₂O₂
Molecular Weight	364.36
SMILES	O=C(C1=CC=C(O1)C2=CC=CC(C(F)(F)F)=C2)N3CCN4CCC3CC4

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.