Neuronal Signaling

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Catalog No.
Product Name
Application
Product Information
Product Citation
  1. Gamma-secretase inhibitor

    FLI-06 is a Notch inhibitor and the early secretory pathway inhibitor. FLI-06 disrupts the Golgi apparatus in a manner distinct from that of brefeldin A and golgicide A.
  2. nAChR agonist

    Sofinicline is a novel nicotinic acetylcholine receptor agonist in the treatment of attention-deficit/hyperactivity disorder.
  3. mAChR antagonist

    AF-DX 384 is a drug which acts as a selective antagonist of the muscarinic acetylcholine receptors.
  4. NMDA receptor ion channel antagonist

    ARL-15896 is a novel N-methyl-D-aspartate receptor ion channel antagonist.
  5. NMDA receptor antagonist

    DNQX is a non-N-methyl-D-aspartate (non-NMDA) receptor complex antagonist.
  6. CaMK/Phosphorylase inhibitor

    K252a is a highly potent cell permeable inhibitor of CaM kinase and phosphorylase kinase (IC50 = 1.8 and 1.7 nmol/L, respectively).
  7. AChE inhibitor

    Desoxypeganine hydrochloride is an AChE (acetylcholinesterase) inhibitor that has been used in the treatment of Alzheimer's dementia.
  8. GABA antagonist

    Cloflubicyne is a potent non-competitive GABA antagonist, convulsant, laboratory insecticide.
  9. COX-2 inhibitor

    ATB-346 exhibits anti-inflammatory properties similar to naproxen, but with substantially reduced gastrointestinal toxicity.
  10. NMDA& mGlu receptor agonist

    Ibotenic acid is a neuroexcitatory amino acid originally isolated from Amanita species that functions as a NMDA and metabotropic glutamate receptor agonist.
  11. NMDA receptors antagonist

    NVP-AAM077 inhibited progenitor cells proliferation in the subventricular zone and dentate gyrus and reduced the survival of newborn cells in the dentate gyrus in the adult mice.
  12. AChE and BChE inhibitor

    Rivastigmine, an cholinesterase inhibitor(IC50= 5.5 uM), inhibits both butyrylcholinesterase and acetylcholinesterase.
  13. nAChR agonist

    Ispronicline is a neuronal nicotinic acetylcholine receptor partial agonist. Ispronicline is subtype-selective, binding primarily to the a4b2 subtype. It has antidepressant, nootropic and neuroprotective effects.
  14. M1 mAChR agonist

    TBPB is an allosteric M1 mAChR agonist with EC50 value of 89 nM that regulates amyloid processing and produces antipsychotic-like activity in rats.
  15. M2/M4 AChR agonist

    LY2119620 is a specific, and allosteric agonist of human M2 and M4 muscarinic acetylcholine receptors.
  16. AchR agonist

    Nitenpyram is a nicotinic acetylcholine receptor (AchR) agonist.
  17. M2/M3 antagonist

    Diphenidol HCl is a potent antagonist of muscarinic M2 and M3 receptor with pKb of 6.72 and 7.02.
  18. Oxiracetam is a cyclic derivative of gamma-aminobutyric acid (GABA).
  19. CaMKII inhibitor

    KN-93 Phosphate is a potent and specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with Ki of 0.37 μM, no remarkable inhibitory effects on APK, PKC, MLCK or Ca2+-PDE activities.
  20. eEF-2 inhibitor

    NH125 is a selective eEF-2 kinase inhibitor.
  21. Benzodiazepine agonist

    a5IA is a nootropic drug invented in 2004 by a team working for Merck, Sharp and Dohme, which acts as a subtype-selective inverse agonist at the benzodiazepine binding site on the GABAA receptor.
  22. benzodiazepine receptor antagonist

    Ro 15-1788 is a benzodiazepine receptor antagonist.
  23. AChE inhibitor

    Pulegone is a monoterpene compound found in a number of essential oils. The unit of Product is ml.
  24. 5-HT3 receptor antagonist

    Tropisetron is a selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ?? 0.9 nM for 5-HT3 receptor.
  25. BACE1 inhibitor

    AMG-8718 is a potent and orally efficacious BACE1 inhibitor.
  26. BACE1 Inhibitor

    Timosaponin B-II is a major active component of Anemarrhena asphodeloides Bunge (Liliaceae, rhizome) that has protective effects against cerebral ischaemic damage.
  27. Peimisine and peiminine production by endophytic fungus Fusarium sp. isolated from Fritillaria unibracteata var. wabensis.
  28. 4-Aminobutyric acid is the chief inhibitory neurotransmitter in the mammalian central nervous system.
  29. P2X7 receptor antagonist

    A 438079 Hcl is a competitive P2X7 receptor antagonist (pIC50 = 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line).
  30. Glycine reuptake inhibitor

    RG1678 (Bitopertin) is a potent and noncompetitive glycine reuptake inhibitor (GlyT1).
  31. Glycine reuptake inhibitor

    RG1678 (Bitopertin) is a potent and noncompetitive glycine reuptake inhibitor (GlyT1).
  32. M1 agonist

    Cevimeline hydrochloride hemihydrate, a novel muscarinic receptor agonist, is a candidate therapeutic drug for xerostomia in Sjogren's syndrome.
  33. Anxiolytic anticonvulsant

    Etifoxine is potentiator of GABAA receptor function in cultured neurons.
  34. Anxiolytic anticonvulsant

    Etifoxine hydrochloride is potentiator of GABAA receptor function in cultured neurons.
  35. nAChR Inhibitor

    EVP-6124 is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs); shows selectivity for α7 nAChRs and did not activate or inhibit heteromeric α4β2 nAChRs.
  36. nAChR Inhibitor

    EVP-6124 hydrochloride is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs). EVP-6124 showed selectivity for α7 nAChRs and did not activate or inhibit heteromeric α4β2 nAChRs.
  37. gamma-secretase modulator

    gamma-secretase modulator 3 is a gamma-secretase modulator.
  38. CaMK-II Inhibitor

    KN-92 is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM).
  39. CaMK-II Inhibitor

    KN-92 hydrochloride is a negative control for KN-93.
  40. CaMKII inhibitor

    KN-92 is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM).
  41. COX-1 Inhibitor

    Paradol is the active flavor constituent of the seeds of Guinea pepper (Aframomum melegueta); Paradol has been found to have antioxidative and antitumor promoting effects
  42. NMDA receptor antagonist

    SDZ 220-581 ammonium salt is a potent, competitive antagonist at the NMDA glutamate receptor subtype(pKi= 7.7).
  43. Muscarinic receptor antagonist

    Umeclidinium bromide(GSK573719A) is a muscarinic receptor antagonist which is useful in treatment of chronic obstructive pulmonary disease (COPD).
  44. GABA-transaminase inhibitor

    Vigabatrin is a structural analog of the inhibitory neurotransmitter ??-aminobutyric acid (GABA) that irreversibly inhibits the catabolism of GABA by GABA transaminase.
  45. Gamma-secretase modulator

    Compound W is a γ-secretase inhibitor that has been shown to lower the levels of secreted Aβ42 and Nβ25.
  46. γ-secretase inhibitor

    JLK 6 is an inhibitor of γ-secretase that selectively inhibits APP cleavage without affecting other γ-secretase-mediated pathways.
  47. γ-secretase inhibitor

    MRK 560 is an orally bioavailable gamma-secretase inhibitor with the ability to markedly reduce Abeta peptide in the brain and CSF of the rat and confirm the utility of the rat for assessing the effects of gamma-secretase inhibitors on central nervous system Abeta(40) levels in vivo.
  48. Amyloid b-peptide (42-1) (human), inactive control for Amyloid b (1-42) peptide.
  49. Amyloid b-Peptide (10-20) (human), soluble amyloid b-peptide fragment that is a substrate for gelatinase A/type IV collagenase/MMP-2 and APP secretase; cleaved between Lys16 and Leu17.
  50. Amyloid b-peptide (25-35) (human), fragment of human amyloid beta-peptide, functionally required for the neurotrophic and neurotoxic effects associated with Alzheimer's disease.

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