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BACE1 inhibitor

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Catalog No. A14407

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
AMG-8718 5mg A14407-5
AMG-8718 10mg A14407-10
AMG-8718 25mg A14407-25

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

AMG-8718 is a potent and orally efficacious BACE1 inhibitor.


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Chemical Information

Catalog Num A14407
Actions Inhibitor
M. Wt 442.44
Formula C25H19FN4O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1215868-94-2
Synonyms AMG 8718, AMG8718
SMILES NC(OC1)=N[[email protected]@]21C3=CC(C4=CC=CN=C4F)=CC=C3OC5=NC=C(C#CC6(C)COC6)C=C52

Biological Activity

AMG-8718 is a potent and orally efficacious BACE1 inhibitor.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.6 mL 113.01 mL 226.02mL
0.5 mM 4.52 mL 22.6 mL 45.2 mL
1 mM 2.26 mL 11.3 mL 22.6 mL
5 mM 0.45 mL 2.26 mL 4.52 mL

*The above data is based on the productmolecular weight 442.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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