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CRBN ligand-8-O-C6-NH2

E3 Ligase Ligand-Linker Conjugate

CRBN ligand-8-O-C6-NH2 is an E3 ligase ligand-linker conjugate that targets the cereblon (CRBN) E3 ubiquitin ligase, facilitating targeted protein degradation. This compound serves as a critical component in the synthesis of PROTAC ERα Degrader-11, thus aiding in the study of estrogen receptor-alpha (ERα) modulation and its associated cellular pathways. Researchers can utilize CRBN ligand-8-O-C6-NH2 for advancing the development of targeted therapeutic strategies in cancer and other diseases influenced by ERα signaling.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2407829-84-7
Applications	E3 Ligase Ligand-Linker Conjugate
Formula	C₂₃H₂₅N₃O₅
Molecular Weight	423.46
SMILES	O=C1C(CCC(N1)=O)N2C(C3=CC(OCCCCCCN)=CC4=CC=CC(C2=O)=C43)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.