Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linkers
Tri(Amino-PEG5-amide)-amine is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of diverse protein ligands for targeted protein degradation, enhancing the efficacy of PROTAC-based therapeutics. Its unique structural features allow for improved solubility and stability, making it suitable for various chemical biology and drug discovery applications. -
PROTAC Linker
endo-BCN-PEG3-NH2 is a PEG-based linker designed for use in the synthesis of PROTACs, targeting protein degradation pathways. Featuring a BCN group, this compound enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, facilitating the formation of complex bioconjugates. Its application in chemical biology makes it a valuable tool for researchers investigating targeted protein degradation mechanisms and developing innovative therapeutic strategies. -
PROTAC Linker
Br-PEG4-THP is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis targeting chimeras). This compound facilitates the selective degradation of target proteins by bridging an E3 ligase and the target protein, enhancing the efficacy of PROTACs. It is ideal for research applications focused on targeted protein degradation and therapeutic development in various disease models. -
PROTAC Linker
16-Aminohexadecanoic acid functions as a PROTAC linker, featuring a long alkane chain with terminal carboxylic acid and amine groups. Its amino group (NH2) readily reacts with carboxylic acids, activated NHS esters, and carbonyls, facilitating the formation of stable amide bonds. This biochemical property makes it a valuable component in the synthesis of PROTACs, enhancing their efficacy in targeted protein degradation studies and drug discovery applications. -
PROTAC Linkers
Bromo-PEG7-alcohol is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a bromine functionality that facilitates the conjugation of target ligands to E3 ligase recognition elements. It is employed in various research applications to enable targeted protein degradation, thereby providing valuable insights into cellular mechanisms and therapeutic potential. -
PROTAC Linkers
BocNH-PEG4-CH2CHO is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound facilitates the selective degradation of target proteins by connecting a ligand that recruits an E3 ubiquitin ligase with a protein of interest. Its versatility makes it suitable for various applications in protein degradation research and drug discovery. -
PROTAC Linkers
N-(PEG3-acid)-N-bis(PEG3-amine) is a polyethylene glycol (PEG)-derived linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound enhances the solubility and stability of PROTACs, facilitating efficient target protein degradation. It serves as a vital component in the development of bifunctional molecules for targeted protein modulation and therapeutic applications. -
PROTAC Linker
Mal-Amido-PEG4-Boc is a PEG-derived linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the conjugation of target proteins to E3 ligases, enabling the targeted degradation of specific proteins within cellular systems. Its incorporation in PROTAC development is crucial for investigating protein homeostasis and therapeutic applications in targeted cancer therapies. -
PROTAC Linker
Monoethyl pimelate acts as a key PROTAC linker, characterized by its alkyl/ether structure. This compound facilitates the synthesis of (S,R,S)-AHPC-Me-C7 ester, a targeted BCL-XL PROTAC degrader. Its application is crucial in the development of molecular degraders for therapeutic research, enabling the selective modulation of protein levels within biological systems. -
PROTAC Linker
Propargyl-PEG4-sulfonic acid serves as a versatile PEG-based linker for the synthesis of PROTACs (proteolysis-targeting chimeras). Its alkyne functional group enables efficient click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions, facilitating the conjugation of azide-containing molecules. This compound is crucial for applications in targeted protein degradation research and functional proteomics, enhancing the development of innovative therapeutic strategies. -
PROTAC Linkers
(10-BRomodecyl)phosphonic acid is a versatile alkyl chain-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It facilitates the recruitment of E3 ligases, promoting targeted protein degradation. This compound is essential for advancing research in targeted therapeutics and protein modulation studies. -
PROTAC Linkers
Mal-PEG8-alcohol functions as a PEG-based linker for the development of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of ligands to target proteins, enhancing the specificity and efficacy of targeted protein degradation. It is instrumental in research aimed at elucidating protein functions and therapeutic development in various diseases, including cancer. -
PROTAC Linker
Mal-PEG6-PFP ester is a PEG-based linker designed for PROTAC (proteolysis-targeting chimera) applications. This compound facilitates the synthesis of PROTAC molecules, enabling targeted protein degradation studies. Its molecular structure enhances solubility and improves the overall efficacy of PROTAC conjugates in research applications focused on targeted protein modulation and therapeutic interventions. -
PROTAC Linkers
1,3-bis(carboxyethoxy)-2,2-bis(carboxyethoxy)propane serves as a PEG-based linker for PROTAC (proteolysis-targeting chimera) synthesis. This compound facilitates the selective degradation of target proteins through targeted ubiquitin-proteasome system engagement. It is crucial for researchers developing novel PROTAC molecules to explore therapeutic avenues in targeted protein degradation. -
PROTAC Linker
N-(Propargyl-PEG4)-biocytin is a PEG-based PROTAC linker designed to facilitate the synthesis of PROTACs. This compound features an alkyne functional group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its unique properties make it a valuable tool for researchers studying targeted protein degradation and expanding the capabilities of PROTAC technology in various biological applications. -
PROTAC Linkers
Propargyl-PEG2-MS is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with azide-containing molecules. Propargyl-PEG2-MS serves as a critical tool for researchers exploring targeted protein degradation and other innovative therapeutic strategies. Its versatility in click chemistry makes it suitable for a variety of biological applications in chemical biology and drug development. -
PROTAC Linker
endo-BCN-PEG2-acid is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a bicyclononyne (BCN) group, facilitating strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its unique chemoselectivity enhances the development of targeted protein degradation applications in various biological research contexts. -
PROTAC Linkers
m-PEG24-alcohol is a polyethylene glycol (PEG) linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimeras) molecules. This compound provides the necessary flexibility and solubility for effective assembly of targeted protein degraders. Its application in PROTAC development enables researchers to investigate the selective degradation of specific proteins, facilitating studies in areas such as cancer treatment and protein homeostasis. -
PROTAC Linker
Bis-Mal-PEG3 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the recruitment of E3 ligases to target proteins, thereby promoting ubiquitination and subsequent degradation. Bis-Mal-PEG3 is essential for researchers developing targeted protein degradation strategies to manipulate cellular pathways and study protein function. -
PROTAC Linkers
HS-PEG7-CH2CH2N3 is a PEG-based linker targeting the development of PROTACs (Proteolysis Targeting Chimeras). It features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing compounds. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN functionalities. This versatile linker is essential for researchers focusing on targeted protein degradation mechanisms in chemical biology. -
PROTAC Linker
Azido-PEG3-C3-OH is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). Featuring an azide group, it serves as a click chemistry reagent capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with compounds featuring DBCO or BCN groups. This versatility makes it a valuable tool in chemical biology and drug development research. -
PROTAC Linkers
t-Boc-N-amido-PEG2-C6-Cl is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features a t-Boc amine group and a chloroalkyl functionality that facilitate the conjugation of target proteins to E3 ligases. Its structure enhances solubility and biocompatibility, making it suitable for various biological applications, including targeted protein degradation studies. -
PROTAC Linker
Azido-PEG8-PFP ester serves as a PEG-based PROTAC linker and is integral to the synthesis of PROTACs. This compound features an azide group that enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-functionalized compounds, making it versatile for constructing targeted protein degradation systems in chemical biology research applications. -
PROTAC Linkers
Mal-amido-PEG9-amine TFA is a PEG-derived linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. It facilitates the conjugation of target proteins to ubiquitin ligases, enabling targeted protein degradation in research applications. This compound is instrumental in the development of novel therapeutic strategies, particularly in oncology and cellular biology. -
PROTAC Linkers
Methyltetrazine-PEG8-acid is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ubiquitin ligases, promoting targeted protein degradation. Its ability to enhance solubility and bioavailability makes it a valuable tool in chemical biology and drug discovery applications focused on protein modulation. -
PROTAC Linker
Thiol-C9-PEG4 is a PEG-based PROTAC linker designed for the synthesis of targeted protein degraders. This linker facilitates the conjugation of ubiquitin ligases to target proteins, promoting selective protein degradation pathways. Its application in PROTAC development aids in advancing research in targeted therapeutics and cellular regulation. -
PROTAC linker
N-(Aminooxy-PEG2)-N-bis(PEG3-propargyl) is a PEG-based linker designed for the synthesis of PROTAC (Proteolysis Targeting Chimeras) compounds. This compound features an alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. It serves as a vital tool for researchers in the field of targeted protein degradation, facilitating the development of novel therapeutic strategies. -
PROTAC Linkers
HO-PEG16-OH is a polyethylene glycol (PEG)-based linker specifically designed for PROTAC (Proteolysis-targeting chimera) applications. This compound facilitates the efficient conjugation of target proteins to E3 ubiquitin ligases, enhancing targeted protein degradation. HO-PEG16-OH is ideal for research in drug development and therapy, providing a versatile tool for the synthesis of innovative PROTAC molecules. -
PROTAC Linker
Propargyl-PEG5-Br is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound contains an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. It plays a crucial role in facilitating targeted protein degradation, making it valuable for research in protein function modulation and therapeutic development. -
PROTAC Linker
Fmoc-PEG1-CH2CH2-NHS ester is a polyethylene glycol (PEG)-derived linker designed for use in PROTAC synthesis. This compound facilitates the conjugation of target-specific ligands to E3 ligase recruiters, enabling targeted protein degradation. Its versatile structure enhances solubility and biocompatibility, making it a valuable tool in drug discovery and research applications focused on protein modulation. -
PROTAC Linker
Mal-PEG2-C2-Boc is a poly(ethylene glycol) (PEG)-based linker designed for PROTAC (proteolysis-targeting chimera) synthesis. This compound facilitates the conjugation of target proteins to E3 ligases, enabling the selective degradation of specific proteins within cells. Its application is crucial in the development of novel therapeutic strategies for various diseases through targeted protein modulation. -
PROTAC Linkers
APN-C3-PEG4-azide is a PEG-based PROTAC linker featuring an azide functional group, designed for the synthesis of PROTACs. It facilitates the copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN moieties. This versatile linker is essential for drug development studies involving targeted protein degradation and can enhance the efficiency of modular PROTAC assembly. -
PROTAC Linkers
Hydroxy-PEG5-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the development of bifunctional molecules that target and degrade specific proteins, enhancing selective protein degradation research. Its incorporation in PROTAC design allows for improved solubility and bioavailability, making it a valuable tool in biochemical and pharmacological studies. -
PROTAC Linker
Bis-propargyl-PEG7 is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This reagent facilitates the construction of polymer-linked multimers of guanosine-3', 5'-cyclic monophosphates. As a click chemistry reagent, Bis-propargyl-PEG7 features an alkyne group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc), enabling efficient conjugation with azide-containing molecules for various biological research applications. -
PROTAC Linker
Tos-PEG4-THP is a polyethylene glycol (PEG) based PROTAC linker designed for the synthesis of PROTAC molecules. This compound facilitates the development of targeted protein degraders, specifically enhancing the degradation of K-Ras through the formation of a PROTAC complex. It is suitable for research applications that involve targeted protein degradation strategies in cellular and molecular biology studies. -
PROTAC Linker
Aminooxy-PEG3-acid is a polyethylene glycol (PEG)-based linker utilized in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the development of PROTACs by providing a flexible and stable connection between the target protein and the E3 ubiquitin ligase. Its key biological activity enhances the efficacy of protein degradation in targeted therapeutics, making it suitable for research in targeted protein modulation and degradation strategies. -
PROTAC Linker
Boc-NH-PEG3-propargyl is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. Its unique structure facilitates efficient conjugation in biochemical applications, making it valuable in targeted protein degradation studies. -
PROTAC Linkers
AM-Imidazole-PA-Boc is a versatile PROTAC linker characterized by its alkyl chain structure. It plays a critical role in the design and synthesis of PROTAC IRAK4 degrader-1, facilitating targeted protein degradation. This compound is essential for researchers exploring the therapeutic potential of targeted protein degradation in various signaling pathways and disease models. -
PROTAC Linker
Boc-Aminooxy-PEG4-Tos is a PEG-based linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). Its aminooxy moiety facilitates the formation of stable covalent bonds with target proteins, enhancing the efficiency of targeted degradation. This compound plays a crucial role in drug discovery and development, particularly in researching targeted protein degradation pathways. -
PROTAC Linker
Benzyl-PEG2-Tos is a polyethylene glycol (PEG) based linker designed specifically for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the efficient degradation of target proteins by promoting the formation of a ternary complex between an E3 ubiquitin ligase and the target protein. Its biocompatibility and solubility characteristics make it suitable for a variety of applications in chemical biology and therapeutic development involving targeted protein degradation strategies. -
PROTAC Linker
Boc-NH-PEG11-OH is a polyethylene glycol (PEG)-based linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the formation of PROTACs that can selectively degrade target proteins through the ubiquitin-proteasome system. Its application is crucial in advancing research in targeted protein degradation and therapeutic development. -
PROTAC Linker
N-Me-N-bis-PEG4 is a polyethylene glycol (PEG)-based linker specifically designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the conjugation of target ligands and E3 ligase binding domains, enhancing the efficacy and selectivity of PROTACs. It is suitable for various bioconjugation applications, enabling researchers to explore targeted protein degradation mechanisms in cellular studies. -
PROTAC Linker
Boc-Piperazine-2-F-Ph-CHO is a specialized PROTAC linker designed for the targeted degradation of proteins through the ubiquitin-proteasome pathway. This compound facilitates the synthesis of bifunctional molecules that can selectively degrade target proteins, making it a valuable tool in chemical biology and drug discovery research. Its unique structure and functionality enable the development of novel therapeutic agents aimed at precise cellular regulation. -
PROTAC Linker
Mal-N-bis(PEG4-C2-acid) is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound effectively facilitates the recruitment of E3 ubiquitin ligases, enabling targeted protein degradation. Its application in research includes the development of novel therapeutic strategies for modulating protein levels in various biological contexts. -
PROTAC Linker
TFP-PEG3-TFP is a PEG-based PROTAC linker designed for the synthesis of PROTAC (PROteolysis TArgeting Chimeras) compounds. This linker facilitates the formation of heterobifunctional molecules that engage E3 ligases for targeted protein degradation. It is suitable for applications in drug development and chemical biology, allowing researchers to explore novel therapeutic strategies through targeted modulation of protein levels. -
PROTAC Linker
Methylamino-PEG2-Boc is a PEG-linked PROTAC linker designed for the synthesis of PROTAC molecules. This compound facilitates the targeted degradation of proteins by enabling the conjugation of E3 ligase recruiters to the target proteins. It is commonly utilized in drug discovery and development studies focusing on selective protein degradation. -
PROTAC Linker
THP-PEG4-OH is a polyethylene glycol (PEG) based linker utilized in the construction of PROTACs (Proteolysis Targeting Chimeras). This linker facilitates the effective targeting and degradation of specific proteins, providing a valuable tool in the study of protein regulation and therapeutic development. Its application in PROTAC synthesis enhances the bioavailability and specificity of these bifunctional molecules, advancing research in targeted protein degradation. -
PROTAC Linker
Propargyl-PEG6-Boc is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis-targeting chimeras). This compound features an alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-functionalized molecules. Propargyl-PEG6-Boc is instrumental in optimizing PROTAC design for targeted protein degradation studies, facilitating the development of novel therapeutic strategies in chemical biology research. -
PROTAC Linker
Biotin-PEG3-oxyamine is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the delivery of E3 ligase recruiters to target proteins, enhancing the selectivity and efficacy of targeted protein degradation. Its biotin moiety allows for convenient isolation and detection of labeled proteins in various biological assays, making it a valuable tool in drug discovery and proteomics research. -
PROTAC Linker
Boc-NH-PPG2 is an alkyl/ether-based linker primarily utilized in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the design of bifunctional molecules that promote the targeted degradation of specific proteins, enabling insights into protein functionality and degradation pathways. Its application is crucial for research projects aimed at advancing targeted protein degradation technologies and developing novel therapeutic strategies.
