Catalog No.
Product Name
Application
Product Information
Citations
-
E3 ligase ligand-Linker Conjugate
(S,R,S,R)-AHPC-Me-CO-C7-N3 is a synthesized E3 ligase ligand-linker conjugate that targets the VHL E3 ligase, which plays a crucial role in cellular protein degradation. This compound facilitates the formation of PROTACs, such as the EZH2 Degrader-28, by linking to specific ligands for protein degradation studies. Its application in PROTAC technology makes it valuable for researchers investigating targeted protein modulation and degradation pathways. -
E3 Ligase Ligand-Linker Conjugate
Thalidomide-O-amido-C3-COOH TFA functions as an E3 ligase ligand-linker conjugate, incorporating a CRBN-based ligand and a flexible linker. This compound serves as a valuable building block for synthesizing PROTACs (Proteolysis Targeting Chimeras). It enables targeted protein degradation, thus facilitating the study of protein functions and interactions in various biological contexts. -
E3 Ligase Ligand-Linker Conjugate
(S,R,S)-AHPC-CO-C-PEG5-amine hydrochloride functions as an E3 ligase ligand-linker conjugate, incorporating a VHL ligand with a (S,R,S)-AHPC-based linker. This compound is designed for use in PROTAC synthesis, facilitating targeted protein degradation in various research applications. Its unique structure allows for the selective recruitment of E3 ligases, making it valuable for studies in protein regulation and therapeutic development. -
E3 Ligase Ligand-Linker Conjugate
(S)-Thalidomide-piperazin besylate is an E3 ligase ligand-linker conjugate that features a cereblon (CRBN)-based ligand. This compound facilitates the synthesis of proteolysis-targeting chimeras (PROTACs) and is significant in research focused on targeted protein degradation. Its unique structure enables selective interaction with E3 ligases, offering valuable insights into protein regulation processes in cellular environments. -
E3 Ligase Ligand-Linker Conjugate
Thalidomide-piperidin-C-piperidin hydrochloride is an E3 ligase ligand-linker conjugate that incorporates a cereblon (CRBN)-based ligand. This compound is used in the synthesis of proteolysis-targeting chimeras (PROTACs), which harness the protein degradation machinery to selectively target proteins for ubiquitin-mediated degradation. Its application is pivotal in studying protein regulation and discovery of novel therapeutic strategies in various diseases. -
E3 ligase ligand-Linker Conjugate
(4R,5S)-Nutlin carboxylic acid-NHC2-PEG2-N3 is an E3 ligase ligand-linker conjugate designed for applications in PROTAC (proteolysis targeting chimera) technology. This compound features the (4R,5S)-Nutlin carboxylic acid, a potent MDM2 inhibitor, facilitating targeted degradation of proteins by linking to an E3 ligase. It is essential for developing PROTACs aimed at directing specific therapeutic pathways for proteins such as EZH2. -
PROTAC α-Synuclein Degrader
PROTAC α-synuclein degrader 5 is a potent small-molecule degrader targeting α-synuclein aggregates through the PROTAC mechanism. This compound demonstrates a DC50 value of 7.51 μM and achieves a maximal degradation rate (Dmax) of 89%. Incorporating the probe molecule sery308 and E3 ligase ligands, this degrader is suitable for research on neurological diseases, facilitating studies on the pathophysiology of synucleinopathies. -
α-synuclein Degrader
PROTAC α-synuclein degrader 3 is a selective degrader targeting α-synuclein via the ubiquitin-proteasome system. This compound facilitates the ubiquitination and subsequent degradation of α-synuclein, making it a valuable tool for researching Parkinson's disease mechanisms. Its unique design incorporates specific ligands and linkers to optimize efficacy in targeted protein degradation, aiding investigations into therapeutic strategies for neurodegenerative disorders. -
Keap1-Cul3 E3 ligase Complex Allosteric Molecular Glues
VVD 065 is an allosteric modulator of the Keap1-Cul3 E3 ligase complex that functions as a molecular glue. By activating KEAP1, VVD 065 promotes the degradation of NRF2, an essential regulator of antioxidant defenses. This compound has demonstrated the ability to inhibit tumor growth in non-small cell lung cancer and esophageal squamous cell carcinoma xenograft models. VVD 065 serves as a valuable tool for research on cancer biology and therapeutic strategies targeting oxidative stress responses. -
Ligand for Target Protein for PROTAC
Nrf2 activator-22 is a ligand specifically targeting the Nrf2 protein, playing a crucial role in the development of PROTAC-based therapeutics. This compound facilitates the synthesis of PROTAC K-Ras Degrader-7, highlighting its potential in targeted protein degradation research. Nrf2 activator-22 is valuable for studies aimed at manipulating oxidative stress responses and related signaling pathways. -
Thrombin Inhibitor
PPACK dihydrochloride is a potent and selective irreversible inhibitor of thrombin. It serves as an alternative anticoagulant to lithium heparin for blood gas and electrolyte analyses in whole blood. Additionally, PPACK dihydrochloride inhibits plasminogen activator (rt-PA), preventing its binding to plasma protease inhibitors. This compound also reduces plasmin-induced endothelial permeability and morphological changes in bovine aortic endothelial cell monolayers, making it suitable for investigations in thrombosis-related research. -
PROTAC Linker
Ms-PEG8-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features a Boc-protected amine that facilitates conjugation to target proteins, enhancing the efficient recruitment of E3 ligases. Ms-PEG8-Boc plays a critical role in research applications focused on targeted protein degradation, enabling the study of protein function and therapeutic development in various disease models. -
PROTAC Linkers
m-PEG2-Amino is a polyethylene glycol (PEG)-based linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the development of targeted protein degradation strategies by providing a flexible and hydrophilic backbone. Its application in the construction of PROTACs enables researchers to enhance the selectivity and efficacy of targeted therapies. -
PROTAC Linker
Succinamic acid functions primarily as a linker in the construction of PROTAC molecules. This compound has been characterized as a weak inhibitor of human LL-xylose reductase, exhibiting an IC50 value of 1.45 mM. Its structural properties make it instrumental in synthesizing compounds such as CQ-16, facilitating advancements in targeted protein degradation research. -
PROTAC Linker
Azido-PEG9-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features an azide group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions, facilitating the conjugation of alkyne- or DBCO/BCN-containing molecules, respectively. Its versatility makes Azido-PEG9-Boc a valuable tool for researchers developing targeted protein degradation strategies. -
PROTAC Linkers
(+)-Biotin-PEG2-hydrazide is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the recruitment of E3 ligases to target proteins, thereby promoting their ubiquitination and subsequent degradation. Its application is critical in the development of novel therapeutic strategies for various diseases, particularly in the field of targeted protein degradation research. -
PROTAC linker
N,N'-bis-(azide-PEG3)-chlorocyclohexenyl Cy7 is a PEG-based linker designed for PROTAC synthesis. It features an azide functional group enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-containing compounds. This versatile linker is valuable for optimizing PROTAC constructs in chemical biology research. -
PROTAC Linker
Boc-NHCH2-Ph-pyrimidine-NH2 serves as a versatile linker for PROTAC (Proteolysis Targeting Chimeras) applications. By facilitating the conjugation of target proteins with E3 ligases, this compound enhances the selective degradation of proteins of interest. Its unique structure allows for improved target engagement and therapeutic potency, making it an essential tool for drug discovery and chemical biology research focused on targeted protein degradation. -
PROTAC Linker
N-Boc-N-bis(PEG3-azide) is a PEG-based PROTAC linker that facilitates the synthesis of targeted protein degraders. This compound features an azide group, enabling it to engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds, making it a versatile tool for researchers in the field of protein degradation and chemical biology. -
PROTAC Linkers
N-Me-N-bis-PEG3 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, thereby enhancing the targeted degradation of specific proteins in cellular studies. Its application is crucial in the development of innovative therapeutics that modulate protein levels to investigate biological pathways and disease mechanisms. -
PROTAC linker
Boc-N-Amido-PEG5-MS is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the selective degradation of target proteins through the recruitment of E3 ligases, enhancing targeted therapeutic strategies in chemical biology. Its application extends to various fields including drug discovery and the development of novel therapeutic agents aimed at specific molecular targets. -
PROTAC Linkers
Propargyl-PEG11-methane serves as a versatile PEG-based linker for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an alkyne group, facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its application in PROTAC design makes it a valuable reagent for targeted protein degradation studies and drug discovery research. -
PROTAC Linker
m-PEG4-propargyl is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs. Featuring an alkyne group, this compound serves as a click chemistry reagent, allowing for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. It is instrumental in the development of targeted protein degradation strategies and can be utilized in various research applications focusing on protein modulation and therapeutic discovery. -
PROTAC Linker
N-(Tos-PEG4)-N-bis(PEG4-Boc) is a PEG-based linker designed for use in the development of PROTAC (proteolysis-targeting chimeras) applications. This compound facilitates the conjugation of ligand-recruiting components to E3 ligase adapters, enabling targeted protein degradation mechanisms. Its flexible PEG structure enhances solubility and biocompatibility, making it suitable for various biochemical and pharmacological investigations in drug discovery and development. -
PROTAC Linker
Boc-Aminooxy-PEG1-C2-NH2 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enhancing the selective degradation of proteins within cellular systems. It is an essential tool for researchers investigating targeted protein modulation and ubiquitin-proteasome system dynamics. -
PROTAC Linker
1,1,1-Trifluoroethyl-PEG4-amine is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the development of targeted protein degradation strategies by linking proteins of interest to E3 ligases, enhancing their ubiquitination and subsequent degradation. Its unique trifluoroethyl moiety provides distinct chemical properties that may improve solubility and linker stability, making it suitable for various applications in chemical biology and drug discovery. -
PROTAC Linkers
N-(DBCO-PEG4)-N-Biotin-PEG4-NHS is a PEG-based linker designed for the synthesis of PROTACs. This reagent features a DBCO group that allows for efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its biotin component enhances labeling and purification processes, making it valuable in target protein degradation studies and other biochemical applications. -
PROTAC Linkers
Boc-NH-PEG10-CH2CH2COOH is a polyethylene glycol (PEG)-derived linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound enhances the solubility and pharmacokinetic properties of PROTACs, promoting efficient protein degradation and targeted therapeutic efficacy. Its carboxylic acid functionality facilitates conjugation to target ligands, making it a valuable tool in chemical biology and drug discovery research focused on novel therapeutics. -
PROTAC Linkers
Benzyl-PEG24-MS is a PEG-based linker designed for use in the synthesis of proteolysis targeting chimeras (PROTACs). This compound facilitates the precise conjugation of target protein ligands and ubiquitin E3 ligase binding domains, enhancing the design of bifunctional molecules for targeted protein degradation. Its unique structure allows for increased solubility and improved biocompatibility, making it suitable for various applications in the study of targeted therapies and protein modulation. -
PROTAC Linkers
Amino-PEG23-amine is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of ligand and E3 ligase components, enhancing the selective degradation of target proteins. Its unique structural properties make it suitable for various applications in target protein modulation and therapeutic development. -
PROTAC Linkers
TCO-PEG6-NHS ester is a PEG-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This intermediary compound facilitates the conjugation of targeting ligands to E3 ligases, thereby enhancing the efficiency of targeted protein degradation. Its versatile applications in drug discovery make it a valuable tool for researchers investigating protein modulation and degradation pathways. -
PROTAC Linkers
6-Maleimidocaproic acid-PFP ester is a versatile PROTAC linker that features an alkyl chain structure. It facilitates the synthesis of Proteolysis Targeting Chimeras (PROTACs) by enabling the conjugation of target proteins to E3 ligases. This reagent is essential for applications in targeted protein degradation studies and can enhance the development of novel therapeutics in cancer research and other diseases. -
PROTAC Linker
3-Hydroxyazetidine-Cyclohexanol serves as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras. Its chemical structure is designed to enhance the efficacy of targeted protein degradation, making it a valuable tool in drug discovery and development research. This compound is instrumental in the synthesis of ALK PROTACs, contributing to advancements in targeted therapies for various cancers. -
PROTAC Linker
Benzyl-PEG8-THP is a PEG-based PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound promotes the targeted degradation of specific proteins through an E3 ubiquitin ligase-mediated pathway. Its application is essential in drug discovery and development for creating novel therapeutics that modulate protein levels in a highly selective manner. -
PROTAC Linker
Ald-Ph-amido-C2-PEG3-NH-Boc is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the development of targeted protein degradation systems by connecting target proteins to E3 ligases. It enhances selectivity and efficiency in protein degradation studies, making it a valuable tool for research in targeted therapeutics and cellular pathways. -
PROTAC linker
Hydroxy-Amino-bis(PEG2-propargyl) serves as a PEG-based PROTAC linker, facilitating the design of proteolysis-targeting chimeras (PROTACs). This versatile compound features an alkyne moiety, enabling its participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. Its application in research supports the development of targeted protein degradation strategies, enhancing the exploration of protein functions and therapeutic interventions. -
PROTAC Linkers
Thiol-C9-PEG4-acid is a PEG-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It facilitates the conjugation of target proteins to E3 ligases, enhancing the degradation of selected proteins within cellular systems. This compound is essential for researchers exploring targeted protein degradation and related therapeutic modalities in various biological contexts. -
PROTAC Linkers
CHO-CH2-PEG1-CH2-Boc is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound facilitates the development of bifunctional molecules that promote targeted degradation of specific proteins, enabling innovative therapeutic strategies. Its hydrophilic nature enhances solubility, making it suitable for various biological applications in chemical biology and medicinal chemistry research. -
PROTAC Linker
Azide-PEG7-Tos is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an azide functional group that enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne-containing molecules. Its versatility in click chemistry expands the potential for targeted protein degradation studies, making it an essential tool for researchers in areas such as drug discovery and targeted therapy development. -
PROTAC Linkers
Bromo-PEG4-NHS ester is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligase recruiting components, enhancing the efficacy of targeted protein degradation. Its versatile chemical properties make it suitable for various applications in chemical biology research, particularly in the development of novel therapeutics focusing on selective protein modulation. -
PROTAC Linkers
Hydroxy-PEG12-Boc is a polyethylene glycol (PEG) linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Its primary mechanism involves facilitating the conjugation of target proteins to E3 ligases, thereby promoting targeted degradation pathways. Hydroxy-PEG12-Boc enhances cellular permeability and solubility of PROTACs, making it essential for studies in targeted protein degradation and cellular biotechnology research. -
PROTAC Linker
Azido-PEG3-phosphonic acid ethyl ester is a PEG-based linker designed for PROTAC synthesis, targeting the ubiquitin-proteasome system to facilitate protein degradation. This compound features an azide group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules that possess DBCO or BCN groups, making it a valuable tool for developing targeted protein degradation strategies in chemical biology research. -
PROTAC Linkers
Azido-PEG8-C1-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an azide group, enabling it to engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-modified compounds. Its versatility in click chemistry makes it an invaluable tool for researchers focused on targeted protein degradation and biochemical studies. -
PROTAC Linkers
Benzyl-PEG9-Ots is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis-targeting chimeras). This compound facilitates targeted protein degradation by linking E3 ligase adapters to a specific protein of interest. Its application in PROTAC development enables advancements in cellular research and therapeutic strategies by modulating protein levels within biological systems. -
PROTAC Linker
Ms-PEG12-m is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This versatile linker facilitates the conjugation of target proteins and E3 ligase moieties, enhancing the pharmacological properties of PROTAC candidates. It is valuable in chemical biology research focused on targeted protein degradation and therapeutic development. -
PROTAC Linkers
m-PEG6-C6-phosphonic acid ethyl ester is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the formation of bifunctional molecules that induce targeted protein degradation through the ubiquitin-proteasome pathway. Its unique structural properties enable efficient conjugation and enhanced solubility, making it suitable for advancing research in targeted therapeutic strategies and drug development. -
PROTAC Linkers
m-PEG4-CH2-methyl ester is a polyethylene glycol (PEG) and alkyl/ester-based PROTAC linker that serves as a crucial component in the synthesis of PROTAC molecules. This versatile linker enhances the solubility and pharmacokinetic properties of the resultant PROTACs. It is primarily utilized in drug discovery and development research, particularly for targeted protein degradation applications. -
PROTAC Linker
Azido-PEG1-methyl ester is a versatile PROTAC linker featuring an azide moiety, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This reagent is a valuable tool in click chemistry, capable of participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing and DBCO or BCN-modified molecules, respectively. Its application enhances the development of targeted protein degradation strategies in chemical biology and drug discovery. -
PROTAC Linker
Methylamino-PEG5-azide is a PEG-based linker designed for use in PROTAC synthesis, targeting protein degradation pathways. Featuring an azide moiety, it participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing partners, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN functionalities. This versatile reagent is essential for the development of novel PROTAC compounds, facilitating targeted protein degradation research and applications in drug discovery. -
PROTAC Linker
Azido-PEG8-C-Boc is a PEG-based linker designed for the synthesis of PROTACs, targeting targeted protein degradation pathways. This compound features an azide functional group, enabling the copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with alkyne-containing molecules, as well as the strain-promoted alkyne-azide cycloaddition (SPAAC) reaction with DBCO or BCN-modified substrates. Its applications are vital in the development of innovative therapeutic strategies in chemical biology and drug discovery.
