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Azido-PEG1-methyl ester

PROTAC Linker

Azido-PEG1-methyl ester is a versatile PROTAC linker featuring an azide moiety, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This reagent is a valuable tool in click chemistry, capable of participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing and DBCO or BCN-modified molecules, respectively. Its application enhances the development of targeted protein degradation strategies in chemical biology and drug discovery.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	1835759-80-2
Applications	PROTAC Linker
Formula	C₆H₁₁N₃O₃
Molecular Weight	173.17
SMILES	O=C(CCOCCN=[N+]=[N-])OC

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.