Fig. 1 · Structure
Documents & Downloads
DBCO-PEG8-NHS ester
PROTAC Linkers
DBCO-PEG8-NHS ester is a PEG-based PROTAC linker designed for effective synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a dibenzocyclooctyne (DBCO) moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. It is widely utilized in chemical biology research for targeted protein degradation and the development of novel therapeutic agents.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2553412-88-5 |
| Applications | PROTAC Linkers |
| Formula | C42H55N3O14 |
| Molecular Weight | 825.90 |
| SMILES | O=C(N1CC2=C(C#CC3=C1C=CC=C3)C=CC=C2)CCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON4C(CCC4=O)=O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.