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Ispinesib (SB-715992)

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KSP Inhibitor

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Catalog No. A10486

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Ispinesib 5mg A10486-5

Regular Price: $90.00

Special Price: $81.00

Ispinesib 10mg A10486-10

Regular Price: $160.00

Special Price: $144.00

Ispinesib 50mg A10486-50

Regular Price: $480.00

Special Price: $432.00

Ispinesib 100mg A10486-100

Regular Price: $800.00

Special Price: $720.00

Ispinesib (SB-715992) 10mM * 1mL in DMSO A10486-10mM-D

Regular Price: $214.00

Special Price: $192.60

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Ispinesib (SB-715992) is a potent inhibitor of kinesin spindle protein, a kinesin motor protein essential for the formation of a bipolar mitotic spindle and cell cycle progression through mitosis.

Ispinesib (SB-715992)

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Chemical Information

Catalog Num A10486
Actions Inhibitor
M. Wt 517.1
Formula C30H33ClN4O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 336113-53-2
Synonyms Ispinesib mesylate,B-715992,CK 0238273
SMILES code CC1=CC=C(C=C1)C(=O)N(CCCN)[[email protected]@H](C2=NC3=C(C=CC(=C3)Cl)C(=O)N2CC4=CC=CC=C4)C(C)C
Chemical Name (R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)-4-methylbenzamide

Biological Activity

Description
Ispinesib (SB-715992) is a potent inhibitor of kinesin spindle protein, a kinesin motor protein essential for the formation of a bipolar mitotic spindle and cell cycle progression through mitosis.
Targets
KSP (HsEg5) (Cell-free assay)
1.7 nM(Ki app)

Solubility

Solubility (25°C)* In vitro DMSO 103 mg/mL (199.2 mM)
Water <1 mg/mL (<1 mM)
Ethanol 103 mg/mL (199.2 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.34 mL 96.69 mL 193.39mL
0.5 mM 3.87 mL 19.34 mL 38.68 mL
1 mM 1.93 mL 9.67 mL 19.34 mL
5 mM 0.39 mL 1.93 mL 3.87 mL

*The above data is based on the productmolecular weight 517.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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