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Biological Activity
Ispinesib (SB-715992) is a potent inhibitor of kinesin spindle protein, a kinesin motor protein essential for the formation of a bipolar mitotic spindle and cell cycle progression through mitosis.
Targets
| KSP (HsEg5) (Cell-free assay) | ||||
| 1.7 nM(Ki app) |
| In vitro | DMSO | 93 mg/mL (179.86 mM) | |
| Water | Insoluble | ||
| Ethanol | 93 mg/mL (179.86 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.34 mL | 96.69 mL | 193.39 mL |
| 0.5 mM | 3.87 mL | 19.34 mL | 38.68 mL |
| 1 mM | 1.93 mL | 9.67 mL | 19.34 mL |
| 5 mM | 0.39 mL | 1.93 mL | 3.87 mL |
*The above data is based on the productmolecular weight 517.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10486 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 336113-53-2 |
| Formula | C30H33ClN4O2 |
| M. Wt | 517.1 |
| Purity | >98% |
| Synonyms | Ispinesib mesylate,B-715992,CK 0238273 |
| SMILES | CC1=CC=C(C=C1)C(=O)N(CCCN)[[email protected]@H](C2=NC3=C(C=CC(=C3)Cl)C(=O)N2CC4=CC=CC=C4)C(C)C |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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