Ispinesib (SB-715992)

Catalog No.: A10486

KSP Inhibitor

Ispinesib (SB-715992)

Ispinesib (SB-715992) Chemical Structure

CAS NO. 336113-53-2

Ispinesib (SB-715992) is a potent inhibitor of kinesin spindle protein, a kinesin motor protein essential for the formation of a bipolar mitotic spindle and cell cycle progression through mitosis.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $90.00

Special Price $81.00

10 mg

Regular Price: $160.00

Special Price $144.00

50 mg

Regular Price: $480.00

Special Price $432.00

100 mg

Regular Price: $800.00

Special Price $720.00

10mM * 1mL in DMSO

Regular Price: $214.00

Special Price $192.60

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Ispinesib (SB-715992) is a potent inhibitor of kinesin spindle protein, a kinesin motor protein essential for the formation of a bipolar mitotic spindle and cell cycle progression through mitosis.
Targets
KSP (HsEg5) (Cell-free assay)
1.7 nM(Ki app)
In vitro DMSO 103 mg/mL (199.2 mM)
Water <1 mg/mL (<1 mM)
Ethanol 103 mg/mL (199.2 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.34 mL 96.69 mL 193.39 mL
0.5 mM 3.87 mL 19.34 mL 38.68 mL
1 mM 1.93 mL 9.67 mL 19.34 mL
5 mM 0.39 mL 1.93 mL 3.87 mL

*The above data is based on the productmolecular weight 517.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10486
Actions Inhibitor
M. Wt 517.1
Formula C30H33ClN4O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 336113-53-2
Synonyms Ispinesib mesylate,B-715992,CK 0238273
SMILES CC1=CC=C(C=C1)C(=O)N(CCCN)[[email protected]@H](C2=NC3=C(C=CC(=C3)Cl)C(=O)N2CC4=CC=CC=C4)C(C)C

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