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Ispinesib (SB-715992)

Catalog No.: A10486

KSP Inhibitor

Ispinesib (SB-715992)

Ispinesib (SB-715992) Chemical Structure

CAS NO. 336113-53-2

Ispinesib (SB-715992) is a potent inhibitor of kinesin spindle protein, a kinesin motor protein essential for the formation of a bipolar mitotic spindle and cell cycle progression through mitosis.

Availability: In stock

Package Price Qty
5 mg
$90.00
10 mg
$160.00
50 mg
$480.00
100 mg
$800.00
10mM * 1mL in DMSO
$214.00
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Biological Activity

Ispinesib (SB-715992) is a potent inhibitor of kinesin spindle protein, a kinesin motor protein essential for the formation of a bipolar mitotic spindle and cell cycle progression through mitosis.
Targets
KSP (HsEg5) (Cell-free assay)
1.7 nM(Ki app)
In vitro DMSO 93 mg/mL (179.86 mM)
Water Insoluble
Ethanol 93 mg/mL (179.86 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.34 mL 96.69 mL 193.39 mL
0.5 mM 3.87 mL 19.34 mL 38.68 mL
1 mM 1.93 mL 9.67 mL 19.34 mL
5 mM 0.39 mL 1.93 mL 3.87 mL

*The above data is based on the productmolecular weight 517.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10486
Actions Inhibitor
CAS No. 336113-53-2
Formula C30H33ClN4O2
M. Wt 517.1
Purity >98%
Synonyms Ispinesib mesylate,B-715992,CK 0238273
SMILES CC1=CC=C(C=C1)C(=O)N(CCCN)[[email protected]@H](C2=NC3=C(C=CC(=C3)Cl)C(=O)N2CC4=CC=CC=C4)C(C)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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