Biological Activity
NPI-2358 is a synthetic analog of NPI-2350, a natural product isolated from Aspergillus sp., which depolymerizes microtubules in A549 human lung carcinoma cells.
Targets
Tubulin | ||||
9.8 nM-18 nM |
In vitro | DMSO | Warmed: 49 mg/mL (145.66 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 29.73 mL | 148.63 mL | 297.27 mL |
0.5 mM | 5.95 mL | 29.73 mL | 59.45 mL |
1 mM | 2.97 mL | 14.86 mL | 29.73 mL |
5 mM | 0.59 mL | 2.97 mL | 5.95 mL |
*The above data is based on the productmolecular weight 336.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10654 |
---|---|
Actions | Inhibitor |
CAS No. | 714272-27-2 |
Formula | C19H20N4O2 |
M. Wt | 336.4 |
Purity | >98% |
Synonyms | NPI2358 |
SMILES | CC(C)(C)C1=C(N=CN1)/C=C\2/C(=O)N/C(=C\C3=CC=CC=C3)/C(=O)N2 |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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