NPI-2358 (Plinabulin)

Catalog No.: A10654

Microtubule Inhibitor

NPI-2358 (Plinabulin)

NPI-2358 (Plinabulin) Chemical Structure

CAS NO. 714272-27-2

NPI-2358 is a synthetic analog of NPI-2350, a natural product isolated from Aspergillus sp., which depolymerizes microtubules in A549 human lung carcinoma cells.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $60.00

Special Price $54.00

10 mg

Regular Price: $100.00

Special Price $90.00

50 mg

Regular Price: $300.00

Special Price $270.00

100 mg

Regular Price: $500.00

Special Price $450.00

10mM * 1mL in DMSO

Regular Price: $99.00

Special Price $89.10

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

NPI-2358 is a synthetic analog of NPI-2350, a natural product isolated from Aspergillus sp., which depolymerizes microtubules in A549 human lung carcinoma cells.
Targets
Tubulin
9.8 nM-18 nM
In vitro DMSO 54 mg/mL heating (160.52 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 29.73 mL 148.63 mL 297.27 mL
0.5 mM 5.95 mL 29.73 mL 59.45 mL
1 mM 2.97 mL 14.86 mL 29.73 mL
5 mM 0.59 mL 2.97 mL 5.95 mL

*The above data is based on the productmolecular weight 336.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A10654
Actions Inhibitor
M. Wt 336.4
Formula C19H20N4O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 714272-27-2
Synonyms NPI2358
SMILES CC(C)(C)C1=C(N=CN1)/C=C\2/C(=O)N/C(=C\C3=CC=CC=C3)/C(=O)N2

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