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NPI-2358 is a synthetic analog of NPI-2350, a natural product isolated from Aspergillus sp., which depolymerizes microtubules in A549 human lung carcinoma cells.
Targets
| Tubulin | ||||
| 9.8 nM-18 nM |
| In vitro | DMSO | Warmed: 49 mg/mL (145.66 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 29.73 mL | 148.63 mL | 297.27 mL |
| 0.5 mM | 5.95 mL | 29.73 mL | 59.45 mL |
| 1 mM | 2.97 mL | 14.86 mL | 29.73 mL |
| 5 mM | 0.59 mL | 2.97 mL | 5.95 mL |
*The above data is based on the productmolecular weight 336.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10654 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 714272-27-2 |
| Formula | C19H20N4O2 |
| M. Wt | 336.4 |
| Purity | >98% |
| Synonyms | NPI2358 |
| SMILES | CC(C)(C)C1=C(N=CN1)/C=C\2/C(=O)N/C(=C\C3=CC=CC=C3)/C(=O)N2 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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