Paclitaxel (Taxol)

Catalog No.: A10689

Microtubule Associated inhibitor

Paclitaxel (Taxol)

Paclitaxel (Taxol) Chemical Structure

CAS NO. 33069-62-4

Paclitaxel (Taxol) is a mitotic inhibitor that stabilizes microtubules and as a result, interferes with the normal breakdown of microtubules during cell division.

Availability: In stock

Package Price Qty
10 mg
$30.00
50 mg
$50.00
100 mg
$80.00
200 mg
$100.00
10mM * 1mL in DMSO
$50.00
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Warning WARNING: Attention California Residents: This product can expose you to chemicals including Paclitaxel (Taxol) , which is known to the State of California to cause cancer and birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Li-Li Li, .et al. Resonance energy transfer sensitises and monitors in situ switching of LOV2-based optogenetic actuators, Nat Commun, 2020, Oct 9;11(1):5107 PMID: 33037199
  • Baglo Y, .et al. Harnessing the Potential Synergistic Interplay Between Photosensitizer Dark Toxicity and Chemotherapy, Photochem Photobiol, 2019, Dec 19 PMID: 31856423
  • Owiti AO, .et al. Strategic Pentablock Copolymer Nanomicellar Formulation for Paclitaxel Delivery System, AAPS PharmSciTech, 2018, Oct;19(7):3110-3122 PMID: 30112614
  • Owiti AO, .et al. PSMA Antibody-Conjugated Pentablock Copolymer Nanomicellar Formulation for Targeted Delivery to Prostate Cancer, AAPS PharmSciTech, 2018, Nov;19(8):3534-3549 PMID: 30151731

Biological Activity

Paclitaxel (Taxol) is a mitotic inhibitor that stabilizes microtubules and as a result, interferes with the normal breakdown of microtubules during cell division.
Targets
Microtubule (human endothelial cells)
0.1 pM
In vitro (25°C) DMSO 152 mg/mL (178 mM)
Water Insoluble
Ethanol 16 mg/mL (18.73 mM)
In vivo 5% DMSO+40% PEG 300+5% Tween 80+ddH2O 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 11.71 mL 58.55 mL 117.11 mL
0.5 mM 2.34 mL 11.71 mL 23.42 mL
1 mM 1.17 mL 5.86 mL 11.71 mL
5 mM 0.23 mL 1.17 mL 2.34 mL

*The above data is based on the productmolecular weight 853.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10689
Actions Inhibitor
CAS No. 33069-62-4
Formula C47H51NO14
M. Wt 853.9
Purity >98%
Synonyms Taxol
SMILES CC1=C2[[email protected]](C(=O)[[email protected]@]3([[email protected]](C[[email protected]@H]4[[email protected]]([[email protected]]3[[email protected]@H]([[email protected]@](C2(C)C)(C[[email protected]@H]1OC(=O)[[email protected]@H]([[email protected]](C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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