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- Yu Pan, .et al. The nature of the modification at position 37 of tRNAPhe correlates with acquired taxol resistance, Nucleic Acids Res, 2021, Jan 11;49(1):38-52 PMID: 33290562
- Li-Li Li, .et al. Resonance energy transfer sensitises and monitors in situ switching of LOV2-based optogenetic actuators, Nat Commun, 2020, Oct 9;11(1):5107 PMID: 33037199
- Baglo Y, .et al. Harnessing the Potential Synergistic Interplay Between Photosensitizer Dark Toxicity and Chemotherapy, Photochem Photobiol, 2019, Dec 19 PMID: 31856423
- Owiti AO, .et al. PSMA Antibody-Conjugated Pentablock Copolymer Nanomicellar Formulation for Targeted Delivery to Prostate Cancer, AAPS PharmSciTech, 2018, Nov;19(8):3534-3549 PMID: 30151731
- Owiti AO, .et al. Strategic Pentablock Copolymer Nanomicellar Formulation for Paclitaxel Delivery System, AAPS PharmSciTech, 2018, Oct;19(7):3110-3122 PMID: 30112614
Biological Activity
Paclitaxel (Taxol) is a mitotic inhibitor that stabilizes microtubules and as a result, interferes with the normal breakdown of microtubules during cell division.
Targets
| Microtubule (human endothelial cells) | ||||
| 0.1 pM |
| In vitro (25°C) | DMSO | 152 mg/mL (178 mM) | |
| Water | Insoluble | ||
| Ethanol | 16 mg/mL (18.73 mM) | ||
| In vivo | 5% DMSO+40% PEG 300+5% Tween 80+ddH2O | 5 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 11.71 mL | 58.55 mL | 117.11 mL |
| 0.5 mM | 2.34 mL | 11.71 mL | 23.42 mL |
| 1 mM | 1.17 mL | 5.86 mL | 11.71 mL |
| 5 mM | 0.23 mL | 1.17 mL | 2.34 mL |
*The above data is based on the productmolecular weight 853.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10689 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 33069-62-4 |
| Formula | C47H51NO14 |
| M. Wt | 853.9 |
| Purity | >98% |
| Synonyms | Taxol |
| SMILES | CC1=C2[[email protected]](C(=O)[[email protected]@]3([[email protected]](C[[email protected]@H]4[[email protected]]([[email protected]]3[[email protected]@H]([[email protected]@](C2(C)C)(C[[email protected]@H]1OC(=O)[[email protected]@H]([[email protected]](C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
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