Epothilone B (EPO906)

Catalog No.: A10360

Microtubule Associated inhibitor

Epothilone B (EPO906)

Epothilone B (EPO906) Chemical Structure

CAS NO. 152044-54-7

Epothilone B is a macrolide that causes the formation of bundles of intracellular microtubules in non-mitotic cells, induces the formation of hyperstable tubulin polymers, and arrests cell cycling in mitosis.

Availability: In stock

Package Price Qty
2 mg
$40.00
5 mg
$70.00
10 mg
$120.00
25 mg
$280.00
10mM * 1mL in DMSO
$161.00
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Biological Activity

Epothilone B is a macrolide that causes the formation of bundles of intracellular microtubules in non-mitotic cells, induces the formation of hyperstable tubulin polymers, and arrests cell cycling in mitosis.
Targets
Tubulin (Cell-free assay)
1.8 μM(EC0.01)
In vitro (25°C) DMSO 93 mg/mL (183.18 mM)
Water Insoluble
Ethanol 93 mg/mL (183.18 mM)
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.7 mL 98.48 mL 196.97 mL
0.5 mM 3.94 mL 19.7 mL 39.39 mL
1 mM 1.97 mL 9.85 mL 19.7 mL
5 mM 0.39 mL 1.97 mL 3.94 mL

*The above data is based on the productmolecular weight 507.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10360
Actions Inhibitor
CAS No. 152044-54-7
Formula C27H41NO6S
M. Wt 507.7
Solubility DMSO
Purity >98%
Synonyms Patupilone, Epothilone-B
SMILES C[[email protected]]1CCC[[email protected]@]2([[email protected]@H](O2)C[[email protected]](OC(=O)C[[email protected]@H](C(C(=O)[[email protected]@H]([[email protected]]1O)C)(C)C)O)/C(=C/C3=CSC(=N3)C)/C)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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