Epothilone B (EPO906)

Catalog No.: A10360

Microtubule Associated inhibitor

Epothilone B (EPO906)

Epothilone B (EPO906) Chemical Structure

CAS NO. 152044-54-7

Epothilone B is a macrolide that causes the formation of bundles of intracellular microtubules in non-mitotic cells, induces the formation of hyperstable tubulin polymers, and arrests cell cycling in mitosis.

Availability: In stock

Package Price Qty
2 mg

Regular Price: $40.00

Special Price $36.00

5 mg

Regular Price: $70.00

Special Price $63.00

10 mg

Regular Price: $120.00

Special Price $108.00

25 mg

Regular Price: $280.00

Special Price $252.00

10mM * 1mL in DMSO

Regular Price: $161.00

Special Price $144.90

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Epothilone B is a macrolide that causes the formation of bundles of intracellular microtubules in non-mitotic cells, induces the formation of hyperstable tubulin polymers, and arrests cell cycling in mitosis.
Targets
Tubulin (Cell-free assay)
1.8 μM(EC0.01)
In vitro (25°C) DMSO 102 mg/mL (200.91 mM)
Water <1 mg/mL (<1 mM)
Ethanol 102 mg/mL (200.91 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.7 mL 98.48 mL 196.97 mL
0.5 mM 3.94 mL 19.7 mL 39.39 mL
1 mM 1.97 mL 9.85 mL 19.7 mL
5 mM 0.39 mL 1.97 mL 3.94 mL

*The above data is based on the productmolecular weight 507.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A10360
Actions Inhibitor
M. Wt 507.7
Formula C27H41NO6S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 152044-54-7
Synonyms Patupilone, Epothilone-B
SMILES C[[email protected]]1CCC[[email protected]@]2([[email protected]@H](O2)C[[email protected]](OC(=O)C[[email protected]@H](C(C(=O)[[email protected]@H]([[email protected]]1O)C)(C)C)O)/C(=C/C3=CSC(=N3)C)/C)C

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