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- Yicheng Zhu, .et al. Combinatrial treatment of anti-High Mobility Group Box-1 monoclonal antibody and epothilone B improves functional recovery after spinal cord contusion injury, Neurosci Res, 2021, Apr 17 PMID: 33864880
Biological Activity
Epothilone B is a macrolide that causes the formation of bundles of intracellular microtubules in non-mitotic cells, induces the formation of hyperstable tubulin polymers, and arrests cell cycling in mitosis.
Targets
| Tubulin (Cell-free assay) | ||||
| 1.8 μM(EC0.01) |
| In vitro (25°C) | DMSO | 93 mg/mL (183.18 mM) | |
| Water | Insoluble | ||
| Ethanol | 93 mg/mL (183.18 mM) | ||
| In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 4 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.7 mL | 98.48 mL | 196.97 mL |
| 0.5 mM | 3.94 mL | 19.7 mL | 39.39 mL |
| 1 mM | 1.97 mL | 9.85 mL | 19.7 mL |
| 5 mM | 0.39 mL | 1.97 mL | 3.94 mL |
*The above data is based on the productmolecular weight 507.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10360 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 152044-54-7 |
| Formula | C27H41NO6S |
| M. Wt | 507.7 |
| Purity | >98% |
| Synonyms | Patupilone, Epothilone-B |
| SMILES | C[[email protected]]1CCC[[email protected]@]2([[email protected]@H](O2)C[[email protected]](OC(=O)C[[email protected]@H](C(C(=O)[[email protected]@H]([[email protected]]1O)C)(C)C)O)/C(=C/C3=CSC(=N3)C)/C)C |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
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