Ixabepilone

Catalog No.: A11449

microtubule inhibitor

Ixabepilone

Ixabepilone Chemical Structure

CAS NO. 219989-84-1

Ixabepilone is an epothilone B analog

Availability: In stock

Package Price Qty
5 mg
$250.00
10 mg
$420.00
25 mg
$840.00
50 mg
$1,450.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Dong-Sheng Cao, .et al. A Multi-Scale Systems Pharmacology Approach Uncovers the Anti-Cancer Molecular Mechanism of Ixabepilone, Eur J Med Chem, 2020, Aug 1;199:112421 PMID: 32428794
  • Hoque M, .et al. Changes in cell morphology guide identification of tubulin as the off-target for protein kinase inhibitors, Pharmacol Res, 2018, Aug;134:166-178 PMID: 29944980
  • APRIL L. RISINGER, .et al. Breast Cancer Cell Lines Exhibit Differential Sensitivities to Microtubule-targeting Drugs Independent of Doubling Time, Anticancer Res, 2015, Nov; 35(11): 5845-5850. PMID: 26504006

Biological Activity

Ixabepilone is an epothilone B analog
Targets
microtubule(tubulin stabilising)
In vitro (25°C) DMSO 95 mg/mL (187.48 mM)
Water Insoluble
Ethanol 95 mg/mL (187.48 mM)
In vivo 2% DMSO+30% PEG 300+2% Tween 80+ddH2O 6 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.74 mL 98.68 mL 197.36 mL
0.5 mM 3.95 mL 19.74 mL 39.47 mL
1 mM 1.97 mL 9.87 mL 19.74 mL
5 mM 0.39 mL 1.97 mL 3.95 mL

*The above data is based on the productmolecular weight 506.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11449
Actions Inhibitor
CAS No. 219989-84-1
Formula C27H42N2O5S
M. Wt 506.7
Purity >98%
Synonyms BMS-24755, Azaepothilone , BMS 247550-1
SMILES C[[email protected]]1CCC[[email protected]@]2([[email protected]@H](O2)C[[email protected]](NC(=O)C[[email protected]@H](C(C(=O)[[email protected]@H]([[email protected]]1O)C)(C)C)O)/C(=C/C3=CSC(=N3)C)/C)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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