GRL-190-21 is a potent inhibitor of SARS-CoV-2 main protease (Mpro), exhibiting a dissociation constant (Ki) of 0.04 nM. This compound demonstrates significant antiviral activity, with an effective concentration (EC50) of 0.26 μM in Vero E6 cells. GRL-190-21 effectively reduces the infectivity, replication, and cytopathic effects of SARS-CoV-2, while maintaining a favorable safety profile with minimal toxicity. This compound is valuable for research focused on antiviral drug development and elucidating coronavirus pathogenesis.
GRL-190-21 is a potent inhibitor of SARS-CoV-2 main protease (Mpro), exhibiting a dissociation constant (Ki) of 0.04 nM. This compound demonstrates significant antiviral activity, with an effective concentration (EC50) of 0.26 μM in Vero E6 cells. GRL-190-21 effectively reduces the infectivity, replication, and cytopathic effects of SARS-CoV-2, while maintaining a favorable safety profile with minimal toxicity. This compound is valuable for research focused on antiviral drug development and elucidating coronavirus pathogenesis.
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