Covidcil-19 is a potent inhibitor targeting the frameshifting element (FSE) of SARS-CoV-2. By binding to the revised attenuator hairpin structure with a dissociation constant (Kd) of 11 nM, Covidcil-19 stabilizes its folded conformation, thereby impairing frameshifting efficiency. Importantly, it does not alter the RNA levels of the SARS-CoV-2 FSE. This compound serves as a valuable tool for investigating viral propagation mechanisms and presents potential applications in antiviral research against SARS-CoV-2.
Covidcil-19 is a potent inhibitor targeting the frameshifting element (FSE) of SARS-CoV-2. By binding to the revised attenuator hairpin structure with a dissociation constant (Kd) of 11 nM, Covidcil-19 stabilizes its folded conformation, thereby impairing frameshifting efficiency. Importantly, it does not alter the RNA levels of the SARS-CoV-2 FSE. This compound serves as a valuable tool for investigating viral propagation mechanisms and presents potential applications in antiviral research against SARS-CoV-2.
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