SARS-CoV-2 3CLpro-IN-14 is an orally active inhibitor of the SARS-CoV-2 3CL protease (3CLpro), a crucial target for antiviral therapy. This compound exhibits robust anti-SARS-CoV-2 activity with an EC50 value of 0.18 μM while displaying low cytotoxicity with a CC50 greater than 50 μM in Vero E6 cells. It is applicable in the research of COVID-19 therapies, particularly for understanding viral replication mechanisms and testing potential antiviral compounds.
SARS-CoV-2 3CLpro-IN-14 is an orally active inhibitor of the SARS-CoV-2 3CL protease (3CLpro), a crucial target for antiviral therapy. This compound exhibits robust anti-SARS-CoV-2 activity with an EC50 value of 0.18 μM while displaying low cytotoxicity with a CC50 greater than 50 μM in Vero E6 cells. It is applicable in the research of COVID-19 therapies, particularly for understanding viral replication mechanisms and testing potential antiviral compounds.
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