N-0920 is a highly potent TMPRSS2 inhibitor, exhibiting an IC50 of 0.35 nM. This compound effectively inhibits the entry of SARS-CoV-2 variants EG.5.1 and JN.1 in Calu-3 cells, demonstrating remarkable picomolar EC50 values of 300 pM and 90 pM, respectively. N-0920 is an essential tool for research into viral entry mechanisms and therapeutic strategies against SARS-CoV-2.
N-0920 is a highly potent TMPRSS2 inhibitor, exhibiting an IC50 of 0.35 nM. This compound effectively inhibits the entry of SARS-CoV-2 variants EG.5.1 and JN.1 in Calu-3 cells, demonstrating remarkable picomolar EC50 values of 300 pM and 90 pM, respectively. N-0920 is an essential tool for research into viral entry mechanisms and therapeutic strategies against SARS-CoV-2.
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